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. 2022 Jun;40(9):4285-4291.
doi: 10.1080/07391102.2020.1852969. Epub 2020 Nov 30.

Nitric oxide boosters as defensive agents against COVID-19 infection: an opinion

Jan Mohammad Mir  1   2 , Ram Charitra Maurya  2
Affiliations

Nitric oxide boosters as defensive agents against COVID-19 infection: an opinion

Jan Mohammad Mir et al. J Biomol Struct Dyn. 2022 Jun.

Abstract

In the prevailing covid times, scientific community is busy in developing vaccine against COVID-19. Under such fascination this article describes the possible role of nitric oxide (NO) releasers in aiding the immune system of a human body against this dreadful pandemic disease. Despite some prodrug antiviral compounds are in practice to recover the patients suffering from covid-19, however, co-morbidity deaths are highest among the total deaths happened so far. This concurrence of a number of diseases in a patient along with this viral infection is indicative of the poor immunity. Literature background supports the use of NO as immunity boosting agent and hence, the nitric oxide releasing compounds could act as lucrative in this context. Some dietary suggestions of NO-containing food items have also been introduced in this article. Also, the profound effect of NO in relieving symptomatic severity of covid-19 has been opined in this work.Communicated by Ramaswamy H. Sarma.

Keywords: Immunity; NO; NO-release; food; synthetic moieties.

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Conflict of interest statement

No conflict of interest was declared by the authors for this work

Figures

None
Graphical abstract
Figure 1.
Figure 1.
NO-containing foods.
Figure 2.
Figure 2.
Examples of some NORMS.
Figure 3.
Figure 3.
Some organic nitrites.
Scheme 1.
Scheme 1.
Mechanism of NO release from SNP.
See this image and copyright information in PMC

References

    1. Akaike, T., & Maeda, H. (2000). Nitric oxide and virus infection. Immunology, 101(3), 300–308. 10.1046/j.1365-2567.2000.00142.x - DOI - PMC - PubMed
    1. Akarid, K., Sinet, M., Desforges, B., & Gougerot-Pocidalo, M. A. (1995). Inhibitory effect of nitric oxide on the replication of a murine retrovirus in vitro and in vivo. Journal of Virology, 69(11), 7001–7005. 10.1128/JVI.69.11.7001-7005.1995 - DOI - PMC - PubMed
    1. Akerstrom, S., Mousavi-Jazi, M., Klingstrom, J., Leijon, M., Lundkvist, A., & Mirazimi, A. (2005). Nitric oxide inhibits the replication cycle of severe acute respiratory syndrome coronavirus. Journal of Virology, 79(3), 1966–1969. 10.1128/JVI.79.3.1966-1969.2005 - DOI - PMC - PubMed
    1. Arnold, W. P., Longnecker, D. E., & Epstein, R. M. (1984). Photodegradation of sodium nitroprusside: Biologic activity and cyanide release. Anesthesiology, 61(3), 254–260. 10.1097/00000542-198409000-00004 - DOI - PubMed
    1. Bates, J. N., Baker, M. T., Guerra, R., Jr., & Harrison, D. G. (1991). Nitric oxide generation from nitroprusside by vascular tissue: Evidence that reduction of the nitroprusside anion and cyanide loss are required. Biochemical Pharmacology, 42, S157–S165. 10.1016/0006-2952(91)90406-U - DOI - PubMed