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Review
. 2021 Apr 1;31(2):39-49.
doi: 10.1097/YPG.0000000000000270.

Understanding the role of gut microbiota in the pathogenesis of schizophrenia

Mahin Ghorbani  1 , Heera Rajandas  1 , Sivachandran Parimannan  1 , Gerard Benedict Stephen Joseph  1 , Mei Mei Tew  2 , Siti Salwa Ramly  3 , Muhammad Arif Muhamad Rasat  4 , Su Yin Lee  1
Affiliations
Review

Understanding the role of gut microbiota in the pathogenesis of schizophrenia

Mahin Ghorbani et al. Psychiatr Genet. .

Abstract

Schizophrenia is a chronic mental disorder with marked symptoms of hallucination, delusion, and impaired cognitive behaviors. Although multidimensional factors have been associated with the development of schizophrenia, the principal cause of the disorder remains debatable. Microbiome involvement in the etiology of schizophrenia has been widely researched due to the advancement in sequencing technologies. This review describes the contribution of the gut microbiome in the development of schizophrenia that is facilitated by the gut-brain axis. The gut microbiota is connected to the gut-brain axis via several pathways and mechanisms, that are discussed in this review. The role of the oral microbiota, probiotics and prebiotics in shaping the gut microbiota are also highlighted. Lastly, future perspectives for microbiome research in schizophrenia are addressed.

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References

    1. Abdel-Haq R, Schlachetzki JCM, Glass CK, Mazmanian SK (2019). Microbiome–microglia connections via the gut–brain axis. J Exp Med. 216:41–59.
    1. Ait-Belgnaoui A, Payard I, Rolland C, Harkat C, Braniste V, Théodorou V, Tompkins TA (2018). Bifidobacterium longum and Lactobacillus helveticus synergistically suppress stress-related visceral hypersensitivity through hypothalamic-pituitary-adrenal axis modulation. J Neurogastroenterol Motil. 24:138–146.
    1. Alam R, Zhou HMAJ (2017). Microbiome, inflammation, epigenetic alterations, and mental diseases. Am J Med Genet B Neuropsychiatr Genet. 174:651–660.
    1. Antonsen S, Mok PLH, Webb RT, Mortensen PB, McGrath JJ, Agerbo E, et al. (2020). Exposure to air pollution during childhood and risk of developing schizophrenia: a national cohort study. Lancet Planet Health. 4:e64–e73.
    1. Arentsen T, Qian Y, Gkotzis S, Femenia T, Wang T, Udekwu K, et al. (2017). The bacterial peptidoglycan-sensing molecule Pglyrp2 modulates brain development and behavior. Mol Psychiatry. 22:257–266.

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