Skip to main page content
U.S. flag

An official website of the United States government

Dot gov

The .gov means it’s official.
Federal government websites often end in .gov or .mil. Before sharing sensitive information, make sure you’re on a federal government site.

Https

The site is secure.
The https:// ensures that you are connecting to the official website and that any information you provide is encrypted and transmitted securely.

Access keys NCBI Homepage MyNCBI Homepage Main Content Main Navigation
Review
. 2021:96:177-216.
doi: 10.1007/978-3-030-58971-4_3.

An Overview of Dps: Dual Acting Nanovehicles in Prokaryotes with DNA Binding and Ferroxidation Properties

Sunanda Margrett Williams  1 , Dipankar Chatterji  2
Affiliations
Review

An Overview of Dps: Dual Acting Nanovehicles in Prokaryotes with DNA Binding and Ferroxidation Properties

Sunanda Margrett Williams et al. Subcell Biochem. 2021.

Abstract

DNA binding proteins under starvation (Dps) are proteins belonging to the ferritin family with the capacity for DNA binding, in addition to iron storage and ferroxidation. Present only in the prokaryotes, these multifaceted proteins have been assigned with a number of roles, from pathogenesis to nucleoid condensation and protection. They have a significant role in protecting the cells from free radical assaults, indirectly by sequestration of iron and by directly binding to the DNA. Due to their symmetry, stability and biomineralization capacity, these proteins have ever increasing potential applications in biotechnology and drug delivery. This chapter tries to bring together all these aspects of Dps in the view of current understanding and older perspectives by studies of our group as well as other experts in the field.

Keywords: Atomic force microscopy; DNA binding proteins; Ferritin family; Iron oxidation; Nanovehicles.

PubMed Disclaimer

References

    1. Alaleona F, Franceschini S, Ceci P, Ilari A, Chiancone E (2010) Thermosynechococcus elongatus DpsA binds Zn(II) at a unique three histidine-containing ferroxidase center and utilizes O2 as iron oxidant with very high efficiency, unlike the typical Dps proteins. FEBS J 277(4):903–917. https://doi.org/10.1111/j.1742-4658.2009.07532.x - DOI - PubMed
    1. Ali Azam T, Iwata A, Nishimura A, Ueda S, Ishihama A (1999) Growth phase-dependent variation in protein composition of the Escherichia coli nucleoid. J Bacteriol 181(20):6361–6370 - DOI
    1. Allen M, Willits D, Young M, Douglas T (2003) Constrained synthesis of cobalt oxide nanomaterials in the 12-subunit protein cage from Listeria innocua. Inorg Chem 42(20):6300–6305. https://doi.org/10.1021/ic0343657 - DOI - PubMed
    1. Almiron M, Link AJ, Furlong D, Kolter R (1992) A novel DNA-binding protein with regulatory and protective roles in starved Escherichia coli. Genes Dev 6(12B):2646–2654. https://doi.org/10.1101/gad.6.12b.2646 - DOI - PubMed
    1. Altuvia S, Almiron M, Huisman G, Kolter R, Storz G (1994) The dps promoter is activated by OxyR during growth and by IHF and sigma S in stationary phase. Mol Microbiol 13(2):265–272. https://doi.org/10.1111/j.1365-2958.1994.tb00421.x - DOI - PubMed

MeSH terms

LinkOut - more resources