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Review
. 2021:96:233-258.
doi: 10.1007/978-3-030-58971-4_5.

The DNA Replication Machine: Structure and Dynamic Function

Nina Y Yao  1 , Michael E O'Donnell  2   3
Affiliations
Review

The DNA Replication Machine: Structure and Dynamic Function

Nina Y Yao et al. Subcell Biochem. 2021.

Abstract

In all cell types, a multi-protein machinery is required to accurately duplicate the large duplex DNA genome. This central life process requires five core replisome factors in all cellular life forms studied thus far. Unexpectedly, three of the five core replisome factors have no common ancestor between bacteria and eukaryotes. Accordingly, the replisome machines of bacteria and eukaryotes have important distinctions in the way that they are organized and function. This chapter outlines the major replication proteins that perform DNA duplication at replication forks, with particular attention to differences and similarities in the strategies used by eukaryotes and bacteria.

Keywords: Clamp loader; DNA polymerase; Helicase; Primase; Replisome; Sliding clamp.

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References

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