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Review
. 2021 Feb;20(2):94-95.
doi: 10.1016/S1474-4422(20)30442-7. Epub 2020 Nov 27.

SARS-CoV-2 and the risk of Parkinson's disease: facts and fantasy

Marcelo Merello, Kailash P Bhatia, Jose A Obeso
Review

SARS-CoV-2 and the risk of Parkinson's disease: facts and fantasy

Marcelo Merello et al. Lancet Neurol. 2021 Feb.
No abstract available

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Figures

Figure
Figure
The relationship between SARS-CoV-2 infection and parkinsonism Acute or subacute parkinsonism can develop as the direct consequence of viral CNS invasion or as a post-infectious inmune-mediated process (scenarios 1 and 2). Pre-symptomatic Parkinson's disease might manifest after a systemic disorder (scenario 3) and, although highly hypothetical, microglia activation and upregulation of α-synuclein triggered by the viral infection could act as the “initial hit” in the multifactorial process that would eventually end in the development of Parkinson's disease (scenario 4). Whether hyposmia is a marker of CNS invasion or of increased risk of parkinsonism is hypothetical.
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