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Review
. 2021 Jan;160(2):556-572.
doi: 10.1053/j.gastro.2020.10.056. Epub 2020 Nov 28.

Chronic Liver Diseases and the Microbiome-Translating Our Knowledge of Gut Microbiota to Management of Chronic Liver Disease

Chathur Acharya  1 , Jasmohan S Bajaj  2
Affiliations
Review

Chronic Liver Diseases and the Microbiome-Translating Our Knowledge of Gut Microbiota to Management of Chronic Liver Disease

Chathur Acharya et al. Gastroenterology. 2021 Jan.

Abstract

Chronic liver disease is reaching epidemic proportions with the increasing prevalence of obesity, nonalcoholic liver disease, and alcohol overuse worldwide. Most patients are not candidates for liver transplantation even if they have end-stage liver disease. There is growing evidence of a gut microbial basis for many liver diseases, therefore, better diagnostic, prognostic, and therapeutic approaches based on knowledge of gut microbiota are needed. We review the questions that need to be answered to successfully translate our knowledge of the intestinal microbiome and the changes associated with liver disease into practice.

Keywords: Cirrhosis; Diet; Fecal Microbial Transplant; Hepatic Encephalopathy.

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Conflict of interest statement

Conflicts of interest

The authors disclose no conflicts.

Figures

Figure 1.
Figure 1.
Current state of microbiome-based diagnostic and therapeutic strategies in CLD: barriers to implementation, deficiencies, and predicted future approaches.
See this image and copyright information in PMC

References

    1. Asrani SK, Devarbhavi H, Eaton J, et al. Burden of liver diseases in the world. J Hepatol 2019;70:151–171. - PubMed
    1. Yoon Y, Chen CM. Surveillance Report No. 105. Liver Cirrhosis Mortality in the United States: National, State, and Regional Trends, 2000–2013. Washington, DC: National Institute on Alcohol Abuse and Alcoholism, Division of Epidemiology and Prevention Research, Alcohol Epidemiologic Data System, 2016.
    1. Trepo E, Romeo S, Zucman-Rossi J, et al. PNPLA3 gene in liver diseases. J Hepatol 2016;65:399–412. - PubMed
    1. Dong XC. PNPLA3-A potential therapeutic target for personalized treatment of chronic liver disease. Front Med (Lausanne) 2019;6:304. - PMC - PubMed
    1. Jepsen P, Vilstrup H, Lash TL. Development and validation of a comorbidity scoring system for patients with cirrhosis. Gastroenterology 2014;146:147–156; quiz e15–e16. - PubMed

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