Skip to main page content
U.S. flag

An official website of the United States government

Dot gov

The .gov means it’s official.
Federal government websites often end in .gov or .mil. Before sharing sensitive information, make sure you’re on a federal government site.

Https

The site is secure.
The https:// ensures that you are connecting to the official website and that any information you provide is encrypted and transmitted securely.

Access keys NCBI Homepage MyNCBI Homepage Main Content Main Navigation
. 2021 Feb;29(2):230-234.
doi: 10.1016/j.joca.2020.09.010. Epub 2020 Nov 27.

Metabolic osteoarthritis - relation of diabetes and cardiovascular disease with knee osteoarthritis

L Kuusalo  1 , D T Felson  2 , N Wang  3 , C E Lewis  4 , J Torner  5 , M C Nevitt  6 , T Neogi  7 ; Multicenter Osteoarthritis Study Group
Affiliations

Metabolic osteoarthritis - relation of diabetes and cardiovascular disease with knee osteoarthritis

L Kuusalo et al. Osteoarthritis Cartilage. 2021 Feb.

Abstract

Objective: There is an interest in identifying a metabolic OA phenotype. We therefore assessed the relation of diabetes and cardiovascular disease to prevalent and incident radiographic (ROA) and symptomatic knee osteoarthritis (SxOA).

Design: In two large cohort studies of individuals with or at risk for knee OA, the Multicenter Osteoarthritis Study (MOST) and Osteoarthritis Initiative (OAI), participants self-reported diabetes and cardiovascular disease (CVD) at baseline. We assessed the relation of baseline diabetes and CVD (exposures) to ROA and SxOA cross-sectionally and after 60 (MOST) or 48 (OAI) months of follow-up using logistic regression with GEE to account for 2 knees within an individual, adjusting for potential confounders.

Results: In MOST, 6,020 knees of 3,021 participants (60.1% female, mean ± SD age 62.5 ± 8.1, mean BMI 30.7 ± 6.0, 83.3% Caucasian) were included in the analyses. In OAI, 8,645 knees of 4,339 participants (58.2% female, mean ± SD age 61.1 ± 9.2, mean BMI 28.6 ± 4.8, 80.3% Caucasian) were included. We found no significant associations between prevalent diabetes or CVD and prevalent or incident ROA or SxOA. Effect estimates for prevalent ROA and SxOA ranged from 0.80 (95% CI 0.63-1.03) to 1.17 (0.91-1.51). Effect estimates for incident ROA ranged from 0.80 (0.58-1.11) to 0.88 (0.60-1.29) in MOST and from 0.75 (0.50-1.14) to 1.19 (0.81-1.74) in OAI, and for incident SxOA from 0.93 (0.65-1.31) to 1.22 (0.89-1.67) in MOST and from 0.82 (0.59-1.16) to 1.19 (0.85-1.66) in OAI).

Conclusions: Diabetes and CVD were not associated with prevalent or incident knee OA.

Keywords: Cardiovascular disease; Diabetes; Knee osteoarthritis; Metabolic.

PubMed Disclaimer

Conflict of interest statement

Competing interest statement

Dr. Kuusalo has provided consulting services to Gilead, Pfizer, and Novartis, and reports lecture and travel fees from Abbvie, Lilly, Novartis, MSD, Orion, Pfizer, and Sanofi outside the submitted work. The other authors report no competing interests.

References

    1. Mobasheri A, Rayman MP, Gualillo O, Sellam J, van der Kraan P, Fearon U. The role of metabolism in the pathogenesis of osteoarthritis. Nat Rev Rheumatol 2017; 13: 302–11. DOI: 10.1038/nrrheum.2017.50. - DOI - PubMed
    1. Louati K, Vidal C, Berenbaum F, Sellam J. Association between diabetes mellitus and osteoarthritis: systematic literature review and meta-analysis. RMD open 2015; 1: e000077-2015-77. DOI: 10.1136/rmdopen-2015-000077. - DOI - PMC - PubMed
    1. Neumann J, Hofmann FC, Heilmeier U, Ashmeik W, Tang K, Gersing AS, et al. Type 2 diabetes patients have accelerated cartilage matrix degeneration compared to diabetes free controls: data from the Osteoarthritis Initiative. Osteoarthritis Cartilage 2018; 26: 751–61. DOI: 10.1016/j.joca.2018.03.010. - DOI - PMC - PubMed
    1. Williams MF, London DA, Husni EM, Navaneethan S, Kashyap SR. Type 2 diabetes and osteoarthritis: a systematic review and meta-analysis. J Diabetes Complications 2016; 30: 944–50. DOI: 10.1016/j.jdiacomp.2016.02.016. - DOI - PubMed
    1. Ong KL, Wu BJ, Cheung BM, Barter PJ, Rye KA. Arthritis: its prevalence, risk factors, and association with cardiovascular diseases in the United States, 1999 to 2008. Ann Epidemiol 2013; 23: 80–6. DOI: 10.1016/j.annepidem.2012.11.008. - DOI - PubMed

Publication types

MeSH terms