Hematological side effects of co-trimoxazole
- PMID: 3325435
- DOI: 10.1007/BF01643198
Hematological side effects of co-trimoxazole
Abstract
Decrease of blood cells may be induced by either components of co-trimoxazole. Side effects of the trimethoprim component are much more frequent, particularly in risk groups. They are dose dependent, usually not severe, only rarely of clinical significance and easily treated or prevented by folate supplementation. In contrast, side effects of the sulfamethoxazole component seem to be extremely rare. They are similar to the hematological side effects of other sulfonamide drugs. They are idiosyncratic, nonpredictable and mostly mediated by the immune-system. They may be of life-threatening severity and no therapy is known except termination of exposure and supportive measures such as substitution of blood cells and antiinfectious therapy by non-related antibiotics.
Similar articles
-
Co-trimoxazole-induced hepatic injury--an analysis of cases with hypersensitivity-like reactions.Infection. 1987;15 Suppl 5:S259-64. doi: 10.1007/BF01643200. Infection. 1987. PMID: 3501774
-
Effect of folic and folinic acid on cytopenia occurring during co-trimoxazole treatment of Pneumocystis carinii pneumonia.Scand J Infect Dis. 1988;20(6):685-6. doi: 10.3109/00365548809035671. Scand J Infect Dis. 1988. PMID: 3265540
-
Co-trimoxazole in pregnancy.Lancet. 1983 Nov 12;2(8359):1142. doi: 10.1016/s0140-6736(83)90657-8. Lancet. 1983. PMID: 6138671 No abstract available.
-
[A case of hypoglycemic attack associated with sulfamethoxazole-trimethoprim].Nihon Naika Gakkai Zasshi. 1987 Dec;76(12):1887-8. doi: 10.2169/naika.76.1887. Nihon Naika Gakkai Zasshi. 1987. PMID: 3330124 Review. Japanese. No abstract available.
-
Trimethoprim-sulfamethoxazole-associated aseptic meningitis: case reports and review of the literature.Am J Med. 1989 Sep;87(3):332-8. doi: 10.1016/s0002-9343(89)80160-3. Am J Med. 1989. PMID: 2672812 Review. No abstract available.
Cited by
-
Friendly fire.NDT Plus. 2011 Jun;4(3):205-7. doi: 10.1093/ndtplus/sfr026. Epub 2011 Mar 17. NDT Plus. 2011. PMID: 25984159 Free PMC article. No abstract available.
-
Prophylactic co-trimoxazole versus norfloxacin in neutropenic children--perspective randomized study.Infection. 1989 Mar-Apr;17(2):65-9. doi: 10.1007/BF01646878. Infection. 1989. PMID: 2654019 Clinical Trial.
-
Safety and efficacy of prophylaxis for Pneumocystis jirovecii pneumonia involving trimethoprim-sulfamethoxazole dose reduction in kidney transplantation.BMC Infect Dis. 2019 Apr 5;19(1):311. doi: 10.1186/s12879-019-3944-0. BMC Infect Dis. 2019. PMID: 30953458 Free PMC article.
-
Aeromonas hydrophila RIT668 and Citrobacter portucalensis RIT669-Potential Zoonotic Pathogens Isolated from Spotted Turtles.Microorganisms. 2020 Nov 17;8(11):1805. doi: 10.3390/microorganisms8111805. Microorganisms. 2020. PMID: 33212916 Free PMC article.
-
Ofloxacin versus trimethoprim-sulfamethoxazole for prevention of infection in patients with acute leukemia and granulocytopenia.Infection. 1991 Mar-Apr;19(2):73-80. doi: 10.1007/BF01645571. Infection. 1991. PMID: 2050424 Clinical Trial.