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. 2020 Nov 24;17(23):8722.
doi: 10.3390/ijerph17238722.

Postmenopausal Breast Cancer in Women, Clinical and Epidemiological Factors Related to the Molecular Subtype: A Retrospective Cohort Study in a Single Institution for 13 Years. Follow-Up Data

Cristina Marinela Oprean  1   2   3 , Serban Mircea Negru  1   2   4 , Dorel Ionel Popovici  1   2   4 , Sorin Saftescu  1   2   4 , Robert-Alexandru Han  2 , Gabriel-Mugurel Dragomir  5 , Teodora Hoinoiu  6 , Alis Dema  3
Affiliations

Postmenopausal Breast Cancer in Women, Clinical and Epidemiological Factors Related to the Molecular Subtype: A Retrospective Cohort Study in a Single Institution for 13 Years. Follow-Up Data

Cristina Marinela Oprean et al. Int J Environ Res Public Health. .

Abstract

This study focused on the characteristics of postmenopausal breast cancer in the population of southeastern Europe. This retrospective study explored the clinical, epidemiological, and molecular characteristics of women with postmenopausal breast cancer.

Material and methods: A retrospective cohort study was performed on 721 postmenopausal breast cancer patients selected from the database of our institution. The data collected consisted of age, living environment, location of the breast tumor, stage of the disease, and molecular sub-type. Patient characteristics were collected based on a systematic chart audit from medical records. The data were analyzed using SPSS 20.0 and Pearson analysis.

Results: The most frequent age range for breast cancer diagnosis was 51 to 70 years old. Most of the patients (80.7%) came from an urban environment. The vast majority of patients were initially diagnosed in stage II (40.3%) and III (30.3%). The most frequent molecular sub-types were luminal B (39%) and luminal A (35.4%). Almost half of the breast tumors were located in the upper outer quadrant (48.8%).

Conclusions: The results of this study describe the profile of patients in southeastern Europe within our institution diagnosed with postmenopausal breast cancer. In our study, patients were first diagnosed with more advanced stages of breast cancer compared with other European countries.

Keywords: breast cancer; location; molecular subtype; postmenopausal status; prognostic factor; stage.

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Conflict of interest statement

The authors declare no conflict of interest. The authors deny any financial interest in the design of the study, in the collection, analyses, or interpretation of data, in the writing of the manuscript or in the decision to publish the results.

Figures

Figure 1
Figure 1
Stage of the disease related to molecular subtype.
See this image and copyright information in PMC

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