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Review
. 2020 Nov 24;10(12):2199.
doi: 10.3390/ani10122199.

State-of-the-Art of the Nutritional Alternatives to the Use of Antibiotics in Humans and Monogastric Animals

Vittorio Saettone  1 , Ilaria Biasato  2 , Elisabetta Radice  3 , Achille Schiavone  1 , Domenico Bergero  1 , Giorgia Meineri  1
Affiliations
Review

State-of-the-Art of the Nutritional Alternatives to the Use of Antibiotics in Humans and Monogastric Animals

Vittorio Saettone et al. Animals (Basel). .

Abstract

In recent years, the indiscriminate use of antibiotics has been perpetrated across human medicine, animals destined for zootechnical productions and companion animals. Apart from increasing the resistance rate of numerous microorganisms and generating multi-drug resistance (MDR), the nonrational administration of antibiotics causes sudden changes in the structure of the intestinal microbiota such as dysbiotic phenomena that can have a great clinical significance for both humans and animals. The aim of this review is to describe the state-of-the-art of alternative therapies to the use of antibiotics and their effectiveness in humans and monogastric animals (poultry, pigs, fish, rabbits, dogs and cats). In particular, those molecules (probiotics, prebiotics and postbiotics) which have a direct function on the gastrointestinal health are herein critically analysed in the prevention or treatment of gastrointestinal diseases or dysbiosis induced by the consumption of antibiotics.

Keywords: antibiotics; dysbiosis; human; intestinal microbiota; monogastric animals; pets; postbiotics; prebiotics; probiotics.

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Conflict of interest statement

The authors declare no conflict of interest.

References

    1. Dodds D.R. Antibiotic resistance: A current epilogue. Biochem. Pharmacol. 2017;134:139–146. doi: 10.1016/j.bcp.2016.12.005. - DOI - PubMed
    1. Breithaupt H. Tackling resistance: Bacteria, humans, animals and the environment: An Interview with Stuart Levy, Professor at Tufts University School of Medicine and President of the Alliance for the Prudent Use of Antibiotics. EMBO Rep. 2014;15:127–130. doi: 10.1002/embr.201338299. - DOI - PMC - PubMed
    1. Ramos S., Chafsey I., Silva N., Hébraud M., Santos H., Capelo-Martinez J.L., Poeta P., Igrejas G. Effect of vancomycin on the proteome of the multiresistant Enterococcus faecium SU18 strain. J. Proteom. 2015;113:378–387. doi: 10.1016/j.jprot.2014.10.012. - DOI - PubMed
    1. Ledingham K., Hinchliffe S., Jackson M., Thomas F., Tomson G. Antibiotic Resistance: Using a Cultural Context of Health Approach to Address a Global Health Challenge. World Health Organization; Copenhagen, Denmark: 2019.
    1. Magiorakos A.P., Srinivasen A., Carey R.B., Carmeli Y., Falagas M.E., Giske C.G., Harbarth S., Hindler J.F., Kahlmeter G., Olsson-LiJequist B., et al. Multidrug-resistant, extensively drug-resistant and pandgrug-resistant bacteria: An international expert proposal for interim standard definitions for acquired resistance. Clin. Microbiol. Infect. 2012;18:268–281. doi: 10.1111/j.1469-0691.2011.03570.x. - DOI - PubMed

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