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Review
. 2020 Nov 24;12(12):3611.
doi: 10.3390/nu12123611.

Role of Oral and Gut Microbiota in Dietary Nitrate Metabolism and Its Impact on Sports Performance

Rocío González-Soltero  1 , María Bailén  1 , Beatriz de Lucas  2 , Maria Isabel Ramírez-Goercke  1 , Helios Pareja-Galeano  2 , Mar Larrosa  2
Affiliations
Review

Role of Oral and Gut Microbiota in Dietary Nitrate Metabolism and Its Impact on Sports Performance

Rocío González-Soltero et al. Nutrients. .

Abstract

Nitrate supplementation is an effective, evidence-based dietary strategy for enhancing sports performance. The effects of dietary nitrate seem to be mediated by the ability of oral bacteria to reduce nitrate to nitrite, thus increasing the levels of nitrite in circulation that may be further reduced to nitric oxide in the body. The gut microbiota has been recently implicated in sports performance by improving muscle function through the supply of certain metabolites. In this line, skeletal muscle can also serve as a reservoir of nitrate. Here we review the bacteria of the oral cavity involved in the reduction of nitrate to nitrite and the possible changes induced by nitrite and their effect on gastrointestinal balance and gut microbiota homeostasis. The potential role of gut bacteria in the reduction of nitrate to nitrite and as a supplier of the signaling molecule nitric oxide to the blood circulation and muscles has not been explored in any great detail.

Keywords: Veillonella; microbiota-muscle axis; nitrate supplementation; nitric oxide; nitrite metabolism; sports performance.

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Conflict of interest statement

The authors declare no conflict of interest.

Figures

Figure 1
Figure 1
Relevant genera of nitrate-reducing bacteria isolated from the oral cavity.
Figure 2
Figure 2
Potential role of nitrogen metabolism in gastrointestinal functions (modified).
See this image and copyright information in PMC

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