Skip to main page content
U.S. flag

An official website of the United States government

Dot gov

The .gov means it’s official.
Federal government websites often end in .gov or .mil. Before sharing sensitive information, make sure you’re on a federal government site.

Https

The site is secure.
The https:// ensures that you are connecting to the official website and that any information you provide is encrypted and transmitted securely.

Access keys NCBI Homepage MyNCBI Homepage Main Content Main Navigation
. 2020 Nov 25;8(4):704.
doi: 10.3390/vaccines8040704.

Adjuvanted Influenza Vaccines Elicits Higher Antibody Responses against the A(H3N2) Subtype than Non-Adjuvanted Vaccines

Laura Sánchez de Prada  1 , Iván Sanz Muñoz  2 , Javier Castrodeza Sanz  1 , Raúl Ortiz de Lejarazu Leonardo  2 , José María Eiros Bouza  2   3
Affiliations

Adjuvanted Influenza Vaccines Elicits Higher Antibody Responses against the A(H3N2) Subtype than Non-Adjuvanted Vaccines

Laura Sánchez de Prada et al. Vaccines (Basel). .

Abstract

Background: vaccination is the best approach to prevent influenza infections so far. Serological studies on the effect of different vaccine types are important to address vaccination campaigns and protect our population. In our study, we compared the serological response against influenza A subtypes using the non-adjuvanted influenza vaccine (NAIV) in adults and the elderly and the adjuvanted influenza vaccine (AIV) in the elderly.

Methods: We performed a retrospective analysis by hemagglutination inhibition assay (HI) of serum samples right before and 28 days after seasonal influenza vaccination during the 1996-2017 seasons.

Conclusions: The AIV presents better performance against the A(H3N2) subtype in the elderly whereas the NAIV induces a better response against A(H1N1)pdm09 in the same group.

Keywords: Vaccines; adjuvanted Vaccines; influenza A.

PubMed Disclaimer

Conflict of interest statement

The authors declare no conflict of interest.

Figures

Figure 1
Figure 1
Pre-vaccination SPR of each cohort against each strain/subtype of influenza A. The line marked with * represent statistically significant (p < 0.05) differences between those two cohorts.
Figure 2
Figure 2
Plots analyzing the effect of the vaccine on the three different age groups for all of the influenza A subtypes analyzed. (A) Post vaccination GMT values. (B) Individual fold-induction (post/pre-HI titers) marked in dots, and the GMT increase marked with a line. (C) Seroconversion rate (percentage of population with 4-folded initial HI titers). Statistical signification between cohorts (p < 0.05) is marked with a line and * in all plots.
Figure 3
Figure 3
Seroprotection rate after vaccination of different age cohorts against influenza A strains/subtypes. Statistical signification between cohorts (p < 0.05) is marked with a line and * in all plots.
See this image and copyright information in PMC

Similar articles

See all similar articles

Cited by

References

    1. Iuliano A.D., Roguski K.M., Chang H.H., Muscatello D.J., Palekar R., Tempia S., Cohen C., Gran J.M., Schanzer D., Cowling B.J., et al. Estimates of global seasonal influenza-associated respiratory mortality: A modelling study. Lancet. 2018;391:1285–1300. doi: 10.1016/S0140-6736(17)33293-2. - DOI - PMC - PubMed
    1. Paules C., Subbarao K. Influenza. Lancet. 2017;390:697–708. doi: 10.1016/S0140-6736(17)30129-0. - DOI - PubMed
    1. Uyeki T.M., Bernstein H.H., Bradley J.S., Englund J.A., File T.M., Fry A.M., Gravenstein S., Hayden F.G., Harper S.A., Hirshon J.M., et al. Clinical Practice Guidelines by the Infectious Diseases Society of America: 2018 Update on Diagnosis, Treatment. Clin. Infect. Dis. 2019;68:1–99. doi: 10.1093/cid/ciy866. - DOI - PMC - PubMed
    1. Arriola C., Garg S., Anderson E.J., Ryan P.A., George A., Zansky S.M., Bennett N., Reingold A., Bargsten M., Miller L., et al. Influenza vaccination modifies disease severity among community-dwelling adults hospitalized with influenza. Clin. Infect. Dis. 2017;65:1289–1297. doi: 10.1093/cid/cix468. - DOI - PMC - PubMed
    1. FranCIs M.E., King M.L., Kelvin A.A. Back to the future for influenza preimmunity—Looking back at influenza virus history to infer the outcome of future infections. Viruses. 2019;11:122. doi: 10.3390/v11020122. - DOI - PMC - PubMed

LinkOut - more resources