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Review
. 2020 Nov 26;12(12):1351.
doi: 10.3390/v12121351.

Adenovirus-Extracellular Protein Interactions and Their Impact on Innate Immune Responses by Human Mononuclear Phagocytes

Coraline Chéneau  1 , Eric J Kremer  1
Affiliations
Review

Adenovirus-Extracellular Protein Interactions and Their Impact on Innate Immune Responses by Human Mononuclear Phagocytes

Coraline Chéneau et al. Viruses. .

Abstract

The aim of this review is to highlight how, in a syngeneic system, human mononuclear phagocytes respond to environments containing human adenovirus (HAdV) and soluble extracellular proteins that influence their innate immune response. Soluble extracellular proteins, including immunoglobulins, blood clotting factors, proteins of the complement system, and/or antimicrobial peptides (AMPs) can exert direct effects by binding to a virus capsid that modifies interactions with pattern recognition receptors and downstream signaling. In addition, the presence, generation, or secretion of extracellular proteins can indirectly influence the response to HAdVs via the activation and recruitment of cells at the site of infection.

Keywords: adenovirus; alarmin; antibody; antimicrobial peptide; coagulation factor; complement; dendritic cell; host defense peptide; innate immunity.

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Conflict of interest statement

The authors declare no conflict of interest.

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