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Review
. 2020 Nov 26;12(12):3535.
doi: 10.3390/cancers12123535.

Perioperative Chemotherapy for Liver Metastasis of Colorectal Cancer

Gloria Chan  1 , Cheng E Chee  1
Affiliations
Review

Perioperative Chemotherapy for Liver Metastasis of Colorectal Cancer

Gloria Chan et al. Cancers (Basel). .

Abstract

The liver is the dominant site of metastasis for patients with colorectal cancer. For those with isolated liver metastases, surgical resection with systemic therapy has led to long-term remission in as high as 80% of patients in well-selected cohorts. This review will focus on how systemic therapy should be integrated with resection of liver metastases; in particular, the use of clinical risk scores based on clinicopathological features that help with patient selection, various approaches to the treatment of micro-metastatic disease (peri-operative versus post-operative chemotherapy), as well as conversion chemotherapy for those with initially upfront unresectable disease will be discussed.

Keywords: colorectal cancer; liver metastasis; neoadjuvant/adjuvant chemotherapy and conversion chemotherapy.

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Conflict of interest statement

The authors declare no conflicts of interests.

Figures

Figure 1
Figure 1
Decision tree for timing and sequence of systemic therapy and surgery for patients with metastatic colorectal cancer to the liver.
See this image and copyright information in PMC

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