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Review
. 2020 Nov 26;25(23):5557.
doi: 10.3390/molecules25235557.

Tetracyclic and Pentacyclic Triterpenes with High Therapeutic Efficiency in Wound Healing Approaches

Roxana Ghiulai  1 , Oana Janina Roşca  1 , Diana Simona Antal  2 , Marius Mioc  1 , Alexandra Mioc  3 , Roxana Racoviceanu  1 , Ioana Macaşoi  4 , Tudor Olariu  5 , Cristina Dehelean  4 , Octavian Marius Creţu  6 , Mirela Voicu  7 , Codruţa Şoica  1
Affiliations
Review

Tetracyclic and Pentacyclic Triterpenes with High Therapeutic Efficiency in Wound Healing Approaches

Roxana Ghiulai et al. Molecules. .

Abstract

Wounds are among the most common skin conditions, displaying a large etiological diversity and being characterized by different degrees of severity. Wound healing is a complex process that involves multiple steps such as inflammation, proliferation and maturation and ends with scar formation. Since ancient times, a widely used option for treating skin wounds are plant- based treatments which currently have become the subject of modern pharmaceutical formulations. Triterpenes with tetracyclic and pentacyclic structure are extensively studied for their implication in wound healing as well as to determine their molecular mechanisms of action. The current review aims to summarize the main results of in vitro, in vivo and clinical studies conducted on lupane, ursane, oleanane, dammarane, lanostane and cycloartane type triterpenes as potential wound healing treatments.

Keywords: pentacyclic triterpenes; tetracyclic triterpenes; wound healing.

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Conflict of interest statement

The authors declare no conflict of interest.

Figures

Figure 1
Figure 1
Skin structure.
Figure 2
Figure 2
Healing cascade phases of acute wounds.
Figure 3
Figure 3
Chemical structures of lupane-skeleton triterpenes.
Figure 4
Figure 4
Chemical structures of ursane-skeleton triterpenes.
Figure 5
Figure 5
Chemical structures of oleanane-skeleton triterpenes A.
Figure 6
Figure 6
Chemical structures of oleanane-skeleton triterpenes B.
Figure 7
Figure 7
Key structural features present in all pentacyclic triterpene structures with wound healing properties (A); superimposed 3D structures of wound healing pentacyclic triterpene structures (B); areas where key functional groups appear are highlighted in yellow; structures that have glycosylated OH or COOH groups, are depicted only as triterpene scaffolds for better image clarity.
Figure 8
Figure 8
Chemical structures of dammarane-type triterpenes.
Figure 9
Figure 9
Chemical structure of cycloastragenol, a lanostane-type triterpenes.
Figure 10
Figure 10
Chemical structure of cycloartane-type triterpenes.
See this image and copyright information in PMC

References

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