Lead-Time Bias as a Potential Explanation for the Link Between Duration of Untreated Psychosis and Outcome: Response to Iyer et al

Affiliations

¹ Department of Psychiatry and Behavioral Health (Jonas, Fochtmann, Perlman, Bromet, Kotov) and Department of Applied Mathematics and Statistics (Tian), Stony Brook University, Stony Brook, N.Y.; Donald and Barbara Zucker School of Medicine at Hofstra/Northwell, Hempstead, New York, and Feinstein Institute for Medical Research, Manhasset, New York (Kane).

Comment

Katherine G Jonas et al. Am J Psychiatry. 2020.

. 2020 Dec 1;177(12):1181-1183.

doi: 10.1176/appi.ajp.2020.20030299r.

¹ Department of Psychiatry and Behavioral Health (Jonas, Fochtmann, Perlman, Bromet, Kotov) and Department of Applied Mathematics and Statistics (Tian), Stony Brook University, Stony Brook, N.Y.; Donald and Barbara Zucker School of Medicine at Hofstra/Northwell, Hempstead, New York, and Feinstein Institute for Medical Research, Manhasset, New York (Kane).

No abstract available

Keywords: Duration of Untreated Psychosis; Early Intervention; Epidemiology; First-Episode Psychosis; Psychosis; Treatment Delay.

Comment on

Lead-Time Bias Confounds Association Between Duration of Untreated Psychosis and Illness Course in Schizophrenia.
Jonas KG, Fochtmann LJ, Perlman G, Tian Y, Kane JM, Bromet EJ, Kotov R. Jonas KG, et al. Am J Psychiatry. 2020 Apr 1;177(4):327-334. doi: 10.1176/appi.ajp.2019.19030324. Epub 2020 Feb 12. Am J Psychiatry. 2020. PMID: 32046533 Free PMC article.
The Case for Cautious Interpretation and Replication: Lead-Time Bias as a Potential Explanation for the Link Between Duration of Untreated Psychosis and Outcome.
Iyer SN, Anderson KK, Malla A, Shah J, Norman R. Iyer SN, et al. Am J Psychiatry. 2020 Dec 1;177(12):1180-1181. doi: 10.1176/appi.ajp.2020.20030299. Am J Psychiatry. 2020. PMID: 33256452 No abstract available.