The Case for Cautious Interpretation and Replication: Lead-Time Bias as a Potential Explanation for the Link Between Duration of Untreated Psychosis and Outcome

Affiliations

¹ Department of Psychiatry and Department of Epidemiology, Biostatistics and Occupational Health, McGill University, Montreal, Canada (Iyer, Malla, Shah); Prevention and Early Intervention Program for Psychosis, Douglas Mental Health University Institute, Montreal, Canada (Iyer, Malla, Shah); Department of Epidemiology and Biostatistics, Schulich School of Medicine and Dentistry, University of Western Ontario, London, Ontario, Canada (Anderson, Norman).

Comment

Srividya N Iyer et al. Am J Psychiatry. 2020.

. 2020 Dec 1;177(12):1180-1181.

doi: 10.1176/appi.ajp.2020.20030299.

¹ Department of Psychiatry and Department of Epidemiology, Biostatistics and Occupational Health, McGill University, Montreal, Canada (Iyer, Malla, Shah); Prevention and Early Intervention Program for Psychosis, Douglas Mental Health University Institute, Montreal, Canada (Iyer, Malla, Shah); Department of Epidemiology and Biostatistics, Schulich School of Medicine and Dentistry, University of Western Ontario, London, Ontario, Canada (Anderson, Norman).

No abstract available

Keywords: Duration of Untreated Psychosis; Early Intervention; Epidemiology; First-Episode Psychosis; Psychosis; Treatment Delay.

Comment in

Lead-Time Bias as a Potential Explanation for the Link Between Duration of Untreated Psychosis and Outcome: Response to Iyer et al.
Jonas KG, Fochtmann LJ, Perlman G, Tian Y, Kane JM, Bromet EJ, Kotov R. Jonas KG, et al. Am J Psychiatry. 2020 Dec 1;177(12):1181-1183. doi: 10.1176/appi.ajp.2020.20030299r. Am J Psychiatry. 2020. PMID: 33256448 No abstract available.

Lead-Time Bias Confounds Association Between Duration of Untreated Psychosis and Illness Course in Schizophrenia.
Jonas KG, Fochtmann LJ, Perlman G, Tian Y, Kane JM, Bromet EJ, Kotov R. Jonas KG, et al. Am J Psychiatry. 2020 Apr 1;177(4):327-334. doi: 10.1176/appi.ajp.2019.19030324. Epub 2020 Feb 12. Am J Psychiatry. 2020. PMID: 32046533 Free PMC article.