The Global Network Maternal Newborn Health Registry: a multi-country, community-based registry of pregnancy outcomes

doi:10.1186/s12978-020-01020-8

Multicenter Study

. 2020 Nov 30;17(Suppl 2):184.

doi: 10.1186/s12978-020-01020-8.

The Global Network Maternal Newborn Health Registry: a multi-country, community-based registry of pregnancy outcomes

Elizabeth M McClure¹, Ana L Garces², Patricia L Hibberd³, Janet L Moore⁴, Shivaprasad S Goudar⁵, Sarah Saleem⁶, Fabian Esamai⁷, Archana Patel⁸, Elwyn Chomba⁹, Adrien Lokangaka, Antoinette Tshefu, Rashidul Haque¹⁰, Carl L Bose¹¹, Edward A Liechty¹², Nancy F Krebs¹³, Richard J Derman¹⁴, Waldemar A Carlo¹⁵, William Petri¹⁶, Marion Koso-Thomas¹⁷, Robert L Goldenberg¹⁸

Affiliations

¹ Social, Statistical and Environmental Health Sciences, RTI International, 3040 Cornwallis Rd., Durham, NC, 27709, USA. mcclure@rti.org.
² Instituto de Nutrición de Centroamérica y Panamá, Guatemala City, Guatemala.
³ School of Public Health, Boston University, Boston, MA, USA.
⁴ Social, Statistical and Environmental Health Sciences, RTI International, 3040 Cornwallis Rd., Durham, NC, 27709, USA.
⁵ KLE Academy Higher Education and Research, J N Medical College, Belagavi, Karnataka, India.
⁶ Aga Khan University, Karachi, Pakistan.
⁷ Moi University School of Medicine, Eldoret, Kenya.
⁸ Lata Medical Research Foundation, Nagpur, India.
⁹ University Teaching Hospital, Lusaka, Zambia.
¹⁰ International Centre for Diarrhoeal Disease Research, Bangladesh (icddr,b), Dhaka, Bangladesh.
¹¹ University of North Carolina At Chapel Hill, Chapel Hill, NC, USA.
¹² Indiana School of Medicine, University of Indiana, Indianapolis, IN, USA.
¹³ University of Colorado School of Medicine, Denver, CO, USA.
¹⁴ Thomas Jefferson University, Philadelphia, USA.
¹⁵ University of Alabama At Birmingham, Birmingham, AL, USA.
¹⁶ University of Virginia, Charlottesville, VA, USA.
¹⁷ Eunice Kennedy Shriver National Institute of Child Health and Human Development, Bethesda, MD, USA.
¹⁸ Department of Obstetrics and Gynecology, Columbia University School of Medicine, New York, NY, USA.

PMID: 33256769
PMCID: PMC7708188
DOI: 10.1186/s12978-020-01020-8

Multicenter Study

The Global Network Maternal Newborn Health Registry: a multi-country, community-based registry of pregnancy outcomes

Elizabeth M McClure et al. Reprod Health. 2020.

. 2020 Nov 30;17(Suppl 2):184.

doi: 10.1186/s12978-020-01020-8.

Authors

Affiliations

¹ Social, Statistical and Environmental Health Sciences, RTI International, 3040 Cornwallis Rd., Durham, NC, 27709, USA. mcclure@rti.org.
² Instituto de Nutrición de Centroamérica y Panamá, Guatemala City, Guatemala.
³ School of Public Health, Boston University, Boston, MA, USA.
⁴ Social, Statistical and Environmental Health Sciences, RTI International, 3040 Cornwallis Rd., Durham, NC, 27709, USA.
⁵ KLE Academy Higher Education and Research, J N Medical College, Belagavi, Karnataka, India.
⁶ Aga Khan University, Karachi, Pakistan.
⁷ Moi University School of Medicine, Eldoret, Kenya.
⁸ Lata Medical Research Foundation, Nagpur, India.
⁹ University Teaching Hospital, Lusaka, Zambia.
¹⁰ International Centre for Diarrhoeal Disease Research, Bangladesh (icddr,b), Dhaka, Bangladesh.
¹¹ University of North Carolina At Chapel Hill, Chapel Hill, NC, USA.
¹² Indiana School of Medicine, University of Indiana, Indianapolis, IN, USA.
¹³ University of Colorado School of Medicine, Denver, CO, USA.
¹⁴ Thomas Jefferson University, Philadelphia, USA.
¹⁵ University of Alabama At Birmingham, Birmingham, AL, USA.
¹⁶ University of Virginia, Charlottesville, VA, USA.
¹⁷ Eunice Kennedy Shriver National Institute of Child Health and Human Development, Bethesda, MD, USA.
¹⁸ Department of Obstetrics and Gynecology, Columbia University School of Medicine, New York, NY, USA.

PMID: 33256769
PMCID: PMC7708188
DOI: 10.1186/s12978-020-01020-8

Abstract

Background: The Global Network for Women's and Children's Health Research (Global Network) conducts clinical trials in resource-limited countries through partnerships among U.S. investigators, international investigators based in in low and middle-income countries (LMICs) and a central data coordinating center. The Global Network's objectives include evaluating low-cost, sustainable interventions to improve women's and children's health in LMICs. Accurate reporting of births, stillbirths, neonatal deaths, maternal mortality, and measures of obstetric and neonatal care is critical to determine strategies for improving pregnancy outcomes. In response to this need, the Global Network developed the Maternal Newborn Health Registry (MNHR), a prospective, population-based registry of pregnant women, fetuses and neonates receiving care in defined catchment areas at the Global Network sites. This publication describes the MNHR, including participating sites, data management and quality and changes over time.

Methods: Pregnant women who reside in or receive healthcare in select communities are enrolled in the MNHR of the Global Network. For each woman and her offspring, sociodemographic, health care, and the major outcomes through 42-days post-delivery are recorded. Study visits occur at enrollment during pregnancy, at delivery and at 42 days postpartum.

Results: From 2010 through 2018, the Global Network MNHR sites were located in Guatemala, Belagavi and Nagpur, India, Pakistan, Democratic Republic of Congo, Kenya, and Zambia. During this period at these sites, 579,140 pregnant women were consented and enrolled in the MNHR, nearly 99% of all eligible women. Delivery data were collected for 99% of enrolled women and 42-day follow-up data for 99% of those delivered. In this supplement, the trends over time and assessment of differences across geographic regions are analyzed in a series of 18 manuscripts utilizing the MNHR data.

Conclusions: Improving maternal, fetal and newborn health in countries with poor outcomes requires an understanding of the characteristics of the population, quality of health care and outcomes. Because the worst pregnancy outcomes typically occur in countries with limited health registration systems and vital records, alternative registration systems may prove to be highly valuable in providing data. The MNHR, an international, multicenter, population-based registry, assesses pregnancy outcomes over time in support of efforts to develop improved perinatal healthcare in resource-limited areas. Trial Registration The Maternal Newborn Health Registry is registered at Clinicaltrials.gov (ID# NCT01073475). Registered February 23, 2019. https://clinicaltrials.gov/ct2/show/NCT01073475.

Keywords: Global network; Maternal mortality; Neonatal mortality; Perinatal mortality; Registry; Stillbirth.

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Conflict of interest statement

The authors have no competing interests.

Figures

**Fig. 1**
Map of Global Network research sites. Note: Original includes those which initiated the study in 2008; current includes those sites active in MNHR as of 2019

**Fig. 2**
Gestational age at enrollment in the Maternal Newborn Health Registry, by year, 2010–2018

**Fig. 3**
Percent of births with weight measured by fetal/neonatal status at delivery and year of MNHR study, 2010–2018

See this image and copyright information in PMC

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References

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1. Blencowe H, Cousens S, Chou D, Oestergaard M, Say L, Moller AB, et al. Born Too Soon Preterm Birth Action Group. Born too soon: the global epidemiology of 15 million preterm births. Reprod Health. 2013;10(Suppl 1):S2. doi: 10.1186/1742-4755-10-S1-S2. - DOI - PMC - PubMed
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[1] GBD 2017 SDG Collaborators Measuring progress from 1990 to 2017 and projecting attainment to 2030 of the health-related Sustainable Development Goals for 195 countries and territories: a systematic analysis for the Global Burden of Disease Study 2017. Lancet. 2018;392:2091–2138. doi: 10.1016/S0140-6736(18)32281-5. - DOI - PMC - PubMed

[2] GBD 2017 SDG Collaborators Measuring progress from 1990 to 2017 and projecting attainment to 2030 of the health-related Sustainable Development Goals for 195 countries and territories: a systematic analysis for the Global Burden of Disease Study 2017. Lancet. 2018;392:2091–2138. doi: 10.1016/S0140-6736(18)32281-5. - DOI - PMC - PubMed

[3] Footman K, Benova C, Goodman C, Macleod D, Lynch CA, Penn-Kekana L, Campbell OMR. Using multi-country household surveys to understand who provides reproductive and maternal health services in low- and middle-income countries: a critical appraisal of the Demographic and Health Surveys. Trop Med Intern Health. 2015;20:589–606. doi: 10.1111/tmi.12471. - DOI - PMC - PubMed

[4] Footman K, Benova C, Goodman C, Macleod D, Lynch CA, Penn-Kekana L, Campbell OMR. Using multi-country household surveys to understand who provides reproductive and maternal health services in low- and middle-income countries: a critical appraisal of the Demographic and Health Surveys. Trop Med Intern Health. 2015;20:589–606. doi: 10.1111/tmi.12471. - DOI - PMC - PubMed

[5] Blencowe H, Cousens S, Chou D, Oestergaard M, Say L, Moller AB, et al. Born Too Soon Preterm Birth Action Group. Born too soon: the global epidemiology of 15 million preterm births. Reprod Health. 2013;10(Suppl 1):S2. doi: 10.1186/1742-4755-10-S1-S2. - DOI - PMC - PubMed

[6] Blencowe H, Cousens S, Chou D, Oestergaard M, Say L, Moller AB, et al. Born Too Soon Preterm Birth Action Group. Born too soon: the global epidemiology of 15 million preterm births. Reprod Health. 2013;10(Suppl 1):S2. doi: 10.1186/1742-4755-10-S1-S2. - DOI - PMC - PubMed

[7] Kodkany B, Derman RJ, Honnungar N, Tyagi N, Goudar SS, Mastiholi S, et al. Establishment of a maternal Newborn Health Registry in the Belgaum District of Karnataka, India. Reprod Health. 2015;12(Suppl 2):S5. - PMC - PubMed

[8] Kodkany B, Derman RJ, Honnungar N, Tyagi N, Goudar SS, Mastiholi S, et al. Establishment of a maternal Newborn Health Registry in the Belgaum District of Karnataka, India. Reprod Health. 2015;12(Suppl 2):S5. - PMC - PubMed

[9] Bose CL, Bauserman M, Goldenberg RL, Goudar SS, McClure EM, Pasha O, et al. The Global Network Maternal Newborn Health Registry: a multi-national, community-based registry of pregnancy outcomes. Reprod Health. 2015;12(Suppl 2):S1. doi: 10.1186/1742-4755-12-S2-S1. - DOI - PMC - PubMed

[10] Bose CL, Bauserman M, Goldenberg RL, Goudar SS, McClure EM, Pasha O, et al. The Global Network Maternal Newborn Health Registry: a multi-national, community-based registry of pregnancy outcomes. Reprod Health. 2015;12(Suppl 2):S1. doi: 10.1186/1742-4755-12-S2-S1. - DOI - PMC - PubMed

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The Global Network Maternal Newborn Health Registry: a multi-country, community-based registry of pregnancy outcomes

Affiliations

The Global Network Maternal Newborn Health Registry: a multi-country, community-based registry of pregnancy outcomes

Authors

Affiliations

Abstract

Conflict of interest statement

Figures

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Cited by

References

Publication types

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Associated data

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Medical