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. 2020 Oct;57(4):175-184.
doi: 10.1053/j.seminhematol.2020.10.004. Epub 2020 Oct 26.

NK cells as adoptive cellular therapy for hematological malignancies: Advantages and hurdles

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NK cells as adoptive cellular therapy for hematological malignancies: Advantages and hurdles

Simona Caruso et al. Semin Hematol. 2020 Oct.

Abstract

Natural killer cells are an essential component of the innate immune system and play a crucial role in immunity against malignancies, without, at difference with T cells, requiring antigen priming or inducing graft-versus-host-disease. Hence, Natural Killer cells can provide a valuable source of allogeneic "off-the-shelf" adoptive therapy and mediate major antileukemia effects, without inducing potentially lethal alloreactivity. Several cell sources have been used for producing and expanding large numbers of clinical-grade natural killer cells. In this review, we will discuss the advantages and challenges of Natural Killer cell-based therapeutic approaches for hematological malignancies, also exploring different strategies to potentiate their clinical application.

Keywords: CAR; Genetic modification; HSC transplantation; Immunotherapy; KIRs; NK cell.

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Conflict of interest statement

Conflicts of interest The authors have no conflicting financial interests.

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