Clock Regulation of Skin Regeneration in Stem Cell Aging

Abstract

The circadian clockwork evolved as an adaptation to daily environmental changes and allows temporal alignment of functions between cells and organs on a systemic level in complex multicellular organisms. These clock functions are particularly important in the skin, which is directly exposed to the external environment. Recent studies have revealed the important impact of circadian rhythmicity on stem cell (SC) homeostasis and regeneration in both young and old skin. This review discusses how the circadian clock regulates tissue function in skin-resident SCs and their niche and how altered daily rhythms in aged SCs negatively affect skin regeneration.