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Comment
. 2021 Feb;44(2):79-81.
doi: 10.1016/j.tins.2020.11.002. Epub 2020 Nov 27.

Parallel Pathways for Mnemonic Processing

Azahara Oliva  1
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Parallel Pathways for Mnemonic Processing

Azahara Oliva. Trends Neurosci. 2021 Feb.

Abstract

In a recent study, Chen et al. showed that divergent subcortical-hippocampal projections are necessary for mnemonic processing. With a combination of elegant experiments, the authors revealed that, whereas a projection from the supramammillary nucleus (SuM) to dentate gyrus (DG) is needed for contextual memory, social memory requires the SuM-CA2 pathway.

Keywords: context; hippocampus; hypothalamus; memory; social.

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  • A hypothalamic novelty signal modulates hippocampal memory.
    Chen S, He L, Huang AJY, Boehringer R, Robert V, Wintzer ME, Polygalov D, Weitemier AZ, Tao Y, Gu M, Middleton SJ, Namiki K, Hama H, Therreau L, Chevaleyre V, Hioki H, Miyawaki A, Piskorowski RA, McHugh TJ. Chen S, et al. Nature. 2020 Oct;586(7828):270-274. doi: 10.1038/s41586-020-2771-1. Epub 2020 Sep 30. Nature. 2020. PMID: 32999460

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