The rationale behind implant coatings to promote osteointegration, bone healing or regeneration

Kai Borcherding¹, Gerhard Schmidmaier², Gunther O Hofmann³, Britt Wildemann⁴

Affiliations

¹ Department of Adhesive Bonding Technology and Surfaces, Fraunhofer Institute for Manufacturing Technology and Advanced Materials IFAM, Bremen, Germany.
² Center for Orthopedics, Trauma Surgery and Spinal Cord Injury, HTRG - Heidelberg Trauma Research Group, Heidelberg University Hospital, Heidelberg, Germany.
³ Department of Trauma, Hand and Reconstructive Surgery, Experimental Trauma Surgery, Jena University Hospital, Friedrich Schiller University Jena, Jena, Germany.
⁴ Department of Trauma, Hand and Reconstructive Surgery, Experimental Trauma Surgery, Jena University Hospital, Friedrich Schiller University Jena, Jena, Germany; Julius Wolff Institute, BIH Center for Regenerative Therapies, Charité-Universitätsmedizin Berlin, Corporate Member of Freie Universität Berlin, Humboldt-Universität zu Berlin, and Berlin Institute of Health, Berlin, Germany. Electronic address: britt.wildemann@med.uni-jena.de.

PMID: 33257018
DOI: 10.1016/j.injury.2020.11.050

Free article

The rationale behind implant coatings to promote osteointegration, bone healing or regeneration

Kai Borcherding et al. Injury. 2021 Jun.

Free article

. 2021 Jun:52 Suppl 2:S106-S111.

doi: 10.1016/j.injury.2020.11.050. Epub 2020 Nov 21.

Authors

Kai Borcherding¹, Gerhard Schmidmaier², Gunther O Hofmann³, Britt Wildemann⁴

Affiliations

¹ Department of Adhesive Bonding Technology and Surfaces, Fraunhofer Institute for Manufacturing Technology and Advanced Materials IFAM, Bremen, Germany.
² Center for Orthopedics, Trauma Surgery and Spinal Cord Injury, HTRG - Heidelberg Trauma Research Group, Heidelberg University Hospital, Heidelberg, Germany.
³ Department of Trauma, Hand and Reconstructive Surgery, Experimental Trauma Surgery, Jena University Hospital, Friedrich Schiller University Jena, Jena, Germany.
⁴ Department of Trauma, Hand and Reconstructive Surgery, Experimental Trauma Surgery, Jena University Hospital, Friedrich Schiller University Jena, Jena, Germany; Julius Wolff Institute, BIH Center for Regenerative Therapies, Charité-Universitätsmedizin Berlin, Corporate Member of Freie Universität Berlin, Humboldt-Universität zu Berlin, and Berlin Institute of Health, Berlin, Germany. Electronic address: britt.wildemann@med.uni-jena.de.

PMID: 33257018
DOI: 10.1016/j.injury.2020.11.050

Abstract

Implant loosening, bone healing failure, implant-associated infections, and large bony defects remain challenges in orthopedic surgery. Implant surface modifications and coatings are being developed to promote osteointegration, prevent colonization by bacteria, and release bioactive factors. The following mini-review briefly discusses the clinical problem, explains the four "osteos", presents examples of coatings used for different orthopedic indications, and finally raises awareness of the coating and translational requirements.

Keywords: Arthroplasty; Coating; Defect; Fracture healing; Osteoconduction; Osteogenesis; Osteoinduction; Osteointegration.

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Conflict of interest statement

Declaration of Competing Interest Gerhard Schmidmaier holds a patent on an implant coating. The other authors have no conflict of interest related to the submitted review.

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The rationale behind implant coatings to promote osteointegration, bone healing or regeneration

Affiliations

The rationale behind implant coatings to promote osteointegration, bone healing or regeneration

Authors

Affiliations

Abstract

Conflict of interest statement

MeSH terms

LinkOut - more resources

Full Text Sources

Other Literature Sources