Full-thickness cartilage graft myringoplasty combined with topical application of bFGF for repair of perforations with extensive epithelialization

Abstract

Objective: The objective of this study is to evaluate the long term outcome of endoscope full-thickness cartilage graft myringoplasty combined with topical application of basic fibroblast growth factor (bFGF) for repair of perforations with extensive epithelialization.

Materials and methods: In total, 65 perforations with extensive epithelialization of edges were divided into the endoscope full-thickness cartilage graft myringoplasty with (bFGF treatment group) and without topical application of bFGF (control group) groups. The outcomes were evaluated in terms of the hearing gain and graft success rate at 12 and 24 months post-surgery.

Results: All patients were followed up at 24 months. Graft success rate was 97.2% in postoperative 12th month and 97.2% in postoperative 24th month in the bFGF group, whereas graft success rate was 100.0% in postoperative 12th month and 86.2% in postoperative 24th month in the control group. The re-perforation wasn't evident in any patients in the bFGF group while re-perforation in 4 (13.8%) patients in the control group, with statistical significance (P = 0.023).Comparing the two groups, there was no difference regardless of in preoperative or postoperative 12 months mean ABG or ABG closure. CT images revealed the well pneumatized middle ear and mastoid cells at postoperative 24th months in both groups, no middle ear cholesteatoma and keratin pearls were found during the period of follow up.

Conclusions: The cartilage-perichondrium double graft combined with bFGF are a feasible and effective method for providing the long-term graft success rate of the perforations with extensive epithelialization.

Keywords: Basic fibroblast growth factor; Cartilage graft; Endoscope; Epithelialization; Myringoplasty.