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. 2021 Feb;18(2):89-90.
doi: 10.1038/s41575-020-00391-4.

Modelling intestinal inflammation and infection using 'mini-gut' organoids

Vivian S W Li  1
Affiliations

Modelling intestinal inflammation and infection using 'mini-gut' organoids

Vivian S W Li. Nat Rev Gastroenterol Hepatol. 2021 Feb.

Abstract

In 2020, major advances to the understanding of gastrointestinal inflammatory and infectious disease have been made using ‘mini-gut’ organoids. Key findings include the discovery of somatic inflammatory gene mutations in ulcerative colitis epithelium, a unique mutational signature in colorectal cancer caused by genotoxic Escherichia coli, and infection of intestinal organoids by SARS-CoV-2.

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Conflict of interest statement

The authors declare no competing interests.

Figures

Fig. 1
Fig. 1. Key applications of patient-derived organoids.
Human intestinal patient-derived organoids can be used for modelling infectious diseases, whole-genome sequencing (WGS), drug screening and regenerative medicine.
See this image and copyright information in PMC

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