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Case Reports
. 2021 May;68(5):e28825.
doi: 10.1002/pbc.28825. Epub 2020 Nov 30.

Previously unreported somatic variants in two patients with pleuropulmonary blastoma with metastatic brain recurrence

Michael J Ferguson  1 , Jennifer Ivanovich  2 , Paige Stansell  1 , Terry A Vik  1 , Amy E Helvie  3 , Morgan R Schmitt  1 , Kris Ann Schultz  4 , Louis P Dehner  4   5 , Jamie L Renbarger  1 , Mark S Marshall  1
Affiliations
Case Reports

Previously unreported somatic variants in two patients with pleuropulmonary blastoma with metastatic brain recurrence

Michael J Ferguson et al. Pediatr Blood Cancer. 2021 May.
No abstract available

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Conflict of interest statement

Conflicts of Interest

The authors of this manuscript have no relevant conflicts of interest to disclose.

Figures

Figure 1.
Figure 1.
Histologic images of initial diagnostic tumor samples. A. 20x view of the first patient tumor which shows scattered large bizarre-appearing anaplastic tumor cells are surrounded by smaller primitive malignant cells. This pattern is a common one in DICER1-associated neoplasms. B. 20x view of the second patient tumor nodule displaying neoplastic cartilage surrounded by a field of primitive tumor cells with a subpopulation of rhabdomyoblasts. This pattern characterizes both pulmonary and extrapulmonary DICER1 neoplasms.
See this image and copyright information in PMC

References

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    1. Hill DA et al. DICER1 mutations in familial pleuropulmonary blastoma. Science. 2009. 325:965. - PMC - PubMed
    1. Schultz KA et al. DICER1 and associated conditions: Identification of at-risk individuals and recommended surveillance strategies. Clinical Cancer Research 2018. 1–11. - PMC - PubMed

Supplementary concepts