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Meta-Analysis
. 2021 Mar 15;35(4):643-653.
doi: 10.1097/QAD.0000000000002780.

Interactive digital interventions for prevention of sexually transmitted HIV

Julia V Bailey  1 , Sonali Wayal  1   2   3 , Catherine R H Aicken  3   4 , Rosie Webster  1 , Catherine H Mercer  3 , Irwin Nazareth  5 , Greta Rait  5 , Richard Peacock  6 , Elizabeth Murray  1
Affiliations
Meta-Analysis

Interactive digital interventions for prevention of sexually transmitted HIV

Julia V Bailey et al. AIDS. .

Abstract

Background: Digital technology offers good opportunities for HIV prevention. This systematic review assesses the effectiveness of interactive digital interventions (IDIs) for prevention of sexually transmitted HIV.

Methods: We conducted a systematic search for randomized controlled trials (RCTs) of IDIs for HIV prevention, defining 'interactive' as producing personally tailored material. We searched databases including the Cochrane Central Register of Controlled Trials, MEDLINE, EMBASE, CINAHL, PsycINFO, grey literature, reference lists, and contacted authors if needed.Two authors screened abstracts, applied eligibility and quality criteria and extracted data. Meta-analyses used random-effects models with standardized mean differences (SMD) for continuous outcomes and odds ratios (OR) for binary outcomes, assessing heterogeneity using the I2 statistic.

Results: We included 31 RCTs of IDIs for HIV prevention. Meta-analyses of 29 RCTs comparing IDIs with minimal interventions (e.g. leaflet, waiting list) showed a moderate increase in knowledge (SMD 0.56, 95% CI 0.33 to 0.80), no effect on self-efficacy (SMD 0.13, 95% CI 0.00 to 0.27), a small improvement in intention (SMD 0.16, 95% CI 0.06 to 0.26), improvement in HIV prevention behaviours (OR 1.28, 95% CI 1.04 to 1.57) and a possible increase in viral load, but this finding is unreliable.We found no evidence of difference between IDIs and face-to-face interventions for knowledge, self-efficacy, intention, or HIV-related behaviours in meta-analyses of five small RCTs. We found no health economic studies.

Conclusion: There is good evidence that IDIs have positive effects on knowledge, intention and HIV prevention behaviours. IDIs are appropriate for HIV prevention in a variety of settings.Supplementary Video Abstract, http://links.lww.com/QAD/B934.

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Conflict of interest statement

There are no conflicts of interest.

Figures

Fig. 1
Fig. 1
Forest plot: interactive digital interventions versus minimal interventions: knowledge.
Fig. 2
Fig. 2
Forest plot: interactive digital interventions versus minimal interventions: self-efficacy.
Fig. 3
Fig. 3
Forest plot: interactive digital interventions versus minimal interventions: intention.
Fig. 4
Fig. 4
Forest plot: interactive digital interventions versus minimal interventions: behaviour.
Fig. 5
Fig. 5
Forest plot: interactive digital interventions versus minimal interventions: biological outcomes.
See this image and copyright information in PMC

References

    1. GBD 2015 HIV Collaborators. Estimates of global, regional, and national incidence, prevalence, and mortality of HIV, 1980-2015: the Global Burden of Disease Study 2015. Lancet HIV 2016; 3:e361–e387. - PMC - PubMed
    1. European Centre for Disease Prevention and Control. Continuum of HIV care. Monitoring implementation of the Dublin Declaration on Partnership to Fight HIV/AIDS in Europe and Central Asia: 2018 progress report, 2019. Available at https://www.ecdc.europa.eu/en/publications-data/continuum-hiv-care-monit... [Accessed 3 December 2020]
    1. UNAIDS. Global HIV & AIDS statistics — 2020 fact sheet. 2020. Available at: https://www.unaids.org/en/resources/fact-sheet [Accessed 3 December 2020]
    1. Bailey JV, Murray E, Rait G, Mercer CH, Morris RW, Peacock R, et al. . Interactive computer-based interventions for sexual health promotion (review). Cochrane Database of Syst Rev 2010; (9):CD006483.DOI: 10.1002/14651858.CD006483.pub2. - PubMed
    1. Krishnaratne S, Hensen B, Cordes J, Enstone J, Hargreaves JR. Interventions to strengthen the HIV prevention cascade: a systematic review of reviews. Lancet HIV 2016; 3:e307–e317. - PubMed