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. 2021 Feb;152(2):220-225.
doi: 10.1002/ijgo.13508. Epub 2020 Dec 18.

Impact of SARS-CoV-2 on multiple gestation pregnancy

Niraj N Mahajan  1 , Munira Ansari  1 , Chaitanya Gaikwad  1 , Priyanka Jadhav  1 , Deepika Tirkey  1 , Madhura P Pophalkar  1 , Aishwarya V Bhurke  2 , Deepak N Modi  2 , Smita D Mahale  2 , Rahul K Gajbhiye  2
Affiliations

Impact of SARS-CoV-2 on multiple gestation pregnancy

Niraj N Mahajan et al. Int J Gynaecol Obstet. 2021 Feb.

Abstract

Objective: To assess clinical presentations, pregnancy complications, and maternal and neonatal outcomes among women with multiple gestation pregnancy (MGP) and confirmed SARS-CoV-2 (COVID-19) infection and to compare the data with a pre-pandemic period.

Methods: A retrospective study at a dedicated COVID-19 Hospital in Mumbai, India. Data were obtained from the PregCovid Registry of pregnant and postpartum women with PCR-confirmed SARS-CoV-2 infection from April to September, 2020. Data were also compared with a cohort of women with MGP attending the hospital pre-pandemic (n = 63).

Results: Data from 879 women (singleton pregnancy, n = 859; MGP, n = 20) with COVID-19 were assessed. The twinning rate was 34.2 per 1000 births. As compared with singleton pregnancies, a higher proportion of women with MGP and Covid-19 delivered preterm (P = 0.001). Spontaneous abortions were also higher in the MGP group than in the singleton group (P = 0.055). The incidence of pre-eclampsia/eclampsia was higher in the COVID-19 MGP group than in both the COVID-19 singleton (41.6% vs. 7.9%) and pre-pandemic MGP (50.0% vs. 12.7%) groups.

Conclusion: There was a higher risk of pre-eclampsia among women with MGP and COVID-19. Women with MGP and COVID-19 infection should receive special attention with a multidisciplinary approach to both maternal and neonatal care during the pandemic.

Keywords: Acute respiratory distress syndrome; COVID-19; Multiple gestation pregnancy; SARS-CoV-2 infection.

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Conflict of interest statement

The authors have no conflicts of interest.

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