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1 Emory University School of Medicine, Department of Human Genetics, 615 Michael Street, Atlanta, GA 30322, USA.
2 Emory University School of Medicine, Department of Human Genetics, 615 Michael Street, Atlanta, GA 30322, USA. Electronic address: vgcorces@gmail.com.
1 Emory University School of Medicine, Department of Human Genetics, 615 Michael Street, Atlanta, GA 30322, USA.
2 Emory University School of Medicine, Department of Human Genetics, 615 Michael Street, Atlanta, GA 30322, USA. Electronic address: vgcorces@gmail.com.
Studies of nuclear architecture using chromosome conformation capture methods have provided a detailed view of how chromatin folds in the 3D nuclear space. New variants of this technology now afford unprecedented resolution and allow the identification of ever smaller folding domains that offer new insights into the mechanisms by which this organization is established and maintained. Here we review recent results in this rapidly evolving field with an emphasis on CTCF function, with the goal of gaining a mechanistic understanding of the principles by which chromatin is folded in the eukaryotic nucleus.
Sabari BR, Dall’Agnese A, Young RA: Biomolecular Condensates in the Nucleus. Trends Biochem Sci 2020: 10.1016/j.tibs.2020.1006.1007.
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Lieberman-Aiden E, van Berkum NL, Williams L, Imakaev M, Ragoczy T, Telling A, Amit I, Lajoie BR, Sabo PJ, Dorschner MO, et al. : Comprehensive mapping of long-range interactions reveals folding principles of the human genome. Science 2009, 326:289–293.
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Dixon JR, Selvaraj S, Yue F, Kim A, Li Y, Shen Y, Hu M, Liu JS, Ren B: Topological domains in mammalian genomes identified by analysis of chromatin interactions. Nature 2012, 485:376–380.
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Rao SSP, Huang SC, Glenn St Hilaire B, Engreitz JM, Perez EM, Kieffer-Kwon KR, Sanborn AL, Johnstone SE, Bascom GD, Bochkov ID, et al. : Cohesin Loss Eliminates All Loop Domains. Cell 2017, 171:305–320 e324.
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Rowley MJ, Nichols MH, Lyu X, Ando-Kuri M, Rivera ISM, Hermetz K, Wang P, Ruan Y, Corces VG: Evolutionarily Conserved Principles Predict 3D Chromatin Organization. Mol Cell 2017, 67:837–852 e837.
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