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Review
. 2021 Aug 28;126(4):552-560.
doi: 10.1017/S0007114520004420. Epub 2020 Nov 5.

Can COVID-19 be a risk for cachexia for patients during intensive care? Narrative review and nutritional recommendations

Isabel P A Virgens  1 , Natália M Santana  1 , Severina C V C Lima  2 , Ana P T Fayh  1   2
Affiliations
Review

Can COVID-19 be a risk for cachexia for patients during intensive care? Narrative review and nutritional recommendations

Isabel P A Virgens et al. Br J Nutr. .

Abstract

Although increased weight, and particularly obesity, has been associated with a more severe clinical course of COVID-19 and risk of fatality, the course of the illness can lead to prolonged length of stay. Changes in nutritional status and weight loss during hospitalisation are largely reported in some populations, but still not explored in COVID-19 patients. Considering that patients with COVID-19 show an increased inflammatory response, other signs and symptoms, which can lead to weight and muscle loss, should be monitored. The aim of this article was to establish possible connections between COVID-19, prolonged hospitalisation and muscle wasting, as well as to propose nutritional recommendations for the prevention and treatment of cachexia, through a narrative review. Identification of risk and presence of malnutrition should be an early step in general assessment of all patients, with regard to more at-risk categories including older adults and individuals suffering from chronic and acute disease conditions, such as COVID-19. The deterioration of nutritional status, and consequently cachexia, increases the risk of mortality and needs to be treated with attention as other complications. There is, however, little hard evidence of nutritional approaches in assisting COVID-19 treatment or its management including cachexia.

Keywords: Coronavirus infections; Diet; Malnutrition; Muscle wasting; Weight loss.

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Figures

None
Graphical abstract
Fig. 1.
Fig. 1.
Symptoms in COVID-19 inpatients related to the onset of cachexia. CRP, C-reactive protein.
See this image and copyright information in PMC

References

    1. Zhu N, Zhang D, Wang W, et al. (2020) A novel coronavirus from patients with pneumonia in China, 2019. N Engl J Med 382, 727–733. - PMC - PubMed
    1. Chen N, Zhou M, Dong X, et al. (2020) Epidemiological and clinical characteristics of 99 cases of 2019 novel coronavirus pneumonia in Wuhan, China: a descriptive study. Lancet 395, 507–513. - PMC - PubMed
    1. Lai C, Shih T, Ko W, et al. (2020) Severe acute respiratory syndrome coronavirus 2 (SARS-CoV-2) and coronavirus disease-2019 (COVID-19): the epidemic and the challenges. Int J Antimicrob Agents 55, 105924. - PMC - PubMed
    1. Guo G, Ye L, Pan K, et al. (2020) New insights of emerging SARS-CoV-2: epidemiology, etiology, clinical features, clinical treatment, and prevention. Front Cell Dev Biol 8, 410. - PMC - PubMed
    1. World Health Organization (2020) Coronavirus disease (COVID-19): weekly epidemiological update, 7 September 2020. World Health Organization. https://apps.who.int/iris/handle/10665/334188.