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Comment
. 2020 Dec;8(12):1464.
doi: 10.1158/2326-6066.CIR-20-0881.

TGFβ: Protecting PD-1 from mRNA Decay

Stephanie K Dougan  1
Affiliations
Comment

TGFβ: Protecting PD-1 from mRNA Decay

Stephanie K Dougan. Cancer Immunol Res. 2020 Dec.

Abstract

Coordinated regulation of genes is key to determining cell fate. Although this is best understood for master regulator transcription factors, posttranscriptional regulation of mRNA stability and nuclear export can be equally effective at altering gene expression. Indeed, the heterogeneity of RNA-binding proteins and miRNAs suggests a deep complexity to posttranscriptional regulatory processes. In this issue, Wu and colleagues report a new mechanism for TGFβ-mediated immune suppression via regulation of mRNA-binding proteins in CD8+ T cells.See article by Wu et al., p. 1470.

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References

    1. Batlle E, Massagué J. Transforming growth factor-β signaling in immunity and cancer. Immunity. 2019;50:924–40.
    1. Dougan M, Dranoff G, Dougan SK. Cancer immunotherapy: beyond checkpoint blockade. Annu Rev Cancer Biol. 2019;3:55–75.
    1. Tian B, Manley JL. Alternative polyadenylation of mRNA precursors. Nat Rev Mol Cell Biol. 2017;18:18–30.
    1. Wu P, Geng B, Chen Q, Zhao E, Liu J, Sun C, et al. Tumor cell-derived TGFβ1 attenuates antitumor immune activity of T cells via regulation of PD-1 mRNA. Cancer Immunol Res. 2020;8:1470–84.

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