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Comment
. 2020 Dec;10(12):1789-1790.
doi: 10.1158/2159-8290.CD-20-1355.

A Sweet Approach to Heat Up Cancer Response to Immunotherapy

Oliver M T Pearce  1 , Heinz Läubli  2
Affiliations
Comment

A Sweet Approach to Heat Up Cancer Response to Immunotherapy

Oliver M T Pearce et al. Cancer Discov. 2020 Dec.

Abstract

Song and colleagues describe how N-glycans stabilize expression of checkpoint molecule B7-H4 that suppresses T-cell function. Inhibiting N-glycan stabilization of B7-H4 generates an immune hot cancer that is more responsive to combination therapies.See related article by Song et al., p. 1872.

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References

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