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Comment
. 2020 Dec;10(12):1791-1793.
doi: 10.1158/2159-8290.CD-20-1333.

BETs Need Greens: Folate Deficiency and Resistance to MYC-Targeted Therapies

Ludovica Marando  1 , Brian J P Huntly  2
Affiliations
Comment

BETs Need Greens: Folate Deficiency and Resistance to MYC-Targeted Therapies

Ludovica Marando et al. Cancer Discov. 2020 Dec.

Abstract

Recently, small-molecule inhibitors of general transcriptional regulators such as BET proteins and the RNA-PolII-regulating kinase CDK7 have been shown to have efficacy in multiple solid and liquid tumors. An article in this issue of Cancer Discovery identifies a nongenetic mechanism of resistance related to deficiency of folate that leads, via increased S-adenosylhomocysteine and reduced repressive histone methylation, to reactivation of a transcriptional program which promotes AML cell survival under the pressure of BET inhibition.See related article by Su et al., p. 1894.

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Comment on

  • The Folate Cycle Enzyme MTHFR Is a Critical Regulator of Cell Response to MYC-Targeting Therapies.
    Su A, Ling F, Vaganay C, Sodaro G, Benaksas C, Dal Bello R, Forget A, Pardieu B, Lin KH, Rutter JC, Bassil CF, Fortin G, Pasanisi J, Antony-Debré I, Alexe G, Benoist JF, Pruvost A, Pikman Y, Qi J, Schlageter MH, Micol JB, Roti G, Cluzeau T, Dombret H, Preudhomme C, Fenouille N, Benajiba L, Golan HM, Stegmaier K, Lobry C, Wood KC, Itzykson R, Puissant A. Su A, et al. Cancer Discov. 2020 Dec;10(12):1894-1911. doi: 10.1158/2159-8290.CD-19-0970. Epub 2020 Aug 21. Cancer Discov. 2020. PMID: 32826232 Free PMC article.

References

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