Skip to main page content
U.S. flag

An official website of the United States government

Dot gov

The .gov means it’s official.
Federal government websites often end in .gov or .mil. Before sharing sensitive information, make sure you’re on a federal government site.

Https

The site is secure.
The https:// ensures that you are connecting to the official website and that any information you provide is encrypted and transmitted securely.

Access keys NCBI Homepage MyNCBI Homepage Main Content Main Navigation
. 1977 Sep;33(3):423-32.

A re-evaluation of the role of macrophages in carrageenan-induced immunosuppression

V M Rumjanek, S R Watson, V S Sljivić

A re-evaluation of the role of macrophages in carrageenan-induced immunosuppression

V M Rumjanek et al. Immunology. 1977 Sep.

Abstract

Administration of a single dose of 1 mg carrageenan to mice cause a temporary blockade of hepatic phagocytosis of 51Cr-labelled sheep erythrocytes (SRBC) and a prolonged reduction in the number of splenic plaque-forming cells (PFC) against SRBC. The in vitro responses to phytohaemagglutinin (PHA) and SRBC were also suppressed, whereas the response to the T cell-independent antigen DNP-Ficoll was not affected. Other in vitro experiments have shown that responses of normal cells can be actively suppressed by macrophages from carrageenan-treated mice and the possible mechanisms of this suppression are discussed.

PubMed Disclaimer

References

    1. Proc Soc Exp Biol Med. 1962 Dec;111:544-7 - PubMed
    1. Br J Pharmacol Chemother. 1954 Mar;9(1):1-14 - PubMed
    1. J Exp Med. 1976 Oct 1;144(4):863-72 - PubMed
    1. Immunology. 1976 Jun;30(6):815-23 - PubMed
    1. Br J Exp Pathol. 1976 Aug;57(4):455-9 - PubMed

LinkOut - more resources