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Comment
. 2020 Dec 29;117(52):32836-32838.
doi: 10.1073/pnas.2022896117. Epub 2020 Dec 1.

Igniting Ca2+ sparks with TRPML1

Gerard P Sergeant  1 , Mark A Hollywood  2 , Keith D Thornbury  2
Affiliations
Comment

Igniting Ca2+ sparks with TRPML1

Gerard P Sergeant et al. Proc Natl Acad Sci U S A. .
No abstract available

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Conflict of interest statement

The authors declare no competing interest.

Figures

Fig. 1.
Fig. 1.
Ca2+ efflux via TRPML1 channels in late endosomes and lysosomes creates a Ca2+ microdomain in the vicinity of neighboring RyR2 channels on the SR that triggers Ca2+ sparks via CICR. Consequently, the initial TRMPL1-mediated Ca2+ release event is amplified by RyR2s to generate a Ca2+ spark that activates BK channels on the plasma membrane.
See this image and copyright information in PMC

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References

    1. Brading A. F., The physiology of the mammalian urinary outflow tract. Exp. Physiol. 84, 215–221 (1999). - PubMed
    1. Griffin C. S., et al. , The intracellular Ca2+ release channel TRPML1 regulates lower urinary tract smooth muscle contractility. Proc. Natl. Acad. Sci. U.S.A. 117, 30775–30786 (2020). - PMC - PubMed
    1. Hashitani H., Brading A. F., Suzuki H., Correlation between spontaneous electrical, calcium and mechanical activity in detrusor smooth muscle of the guinea-pig bladder. Br. J. Pharmacol. 141, 183–193 (2004). - PMC - PubMed
    1. Petkov G. V., Central role of the BK channel in urinary bladder smooth muscle physiology and pathophysiology. Am. J. Physiol. Regul. Integr. Comp. Physiol. 307, R571–R584 (2014). - PMC - PubMed
    1. Meredith A. L., Thorneloe K. S., Werner M. E., Nelson M. T., Aldrich R. W., Overactive bladder and incontinence in the absence of the BK large conductance Ca2+-activated K+ channel. J. Biol. Chem. 279, 36746–36752 (2004). - PubMed

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