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Case Reports
. 2021 May;19(3):257-260.
doi: 10.2450/2020.0247-20. Epub 2020 Nov 27.

Spontaneous splenic rupture due to extramedullary haematopoiesis in a patient with inherited thrombocytopenia

Carlo Zaninetti  1   2   3 , Clara Sacco  4 , Daoud Rahal  5 , Serena Barozzi  1 , Carlo L Balduini  1   6 , Corrado Lodigiani  4 , Alessandro Pecci  1
Affiliations
Case Reports

Spontaneous splenic rupture due to extramedullary haematopoiesis in a patient with inherited thrombocytopenia

Carlo Zaninetti et al. Blood Transfus. 2021 May.
No abstract available

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Conflict of interest statement

The Authors declare no conflict of interests.

Figures

Figure 1
Figure 1
Imaging of spontaneous splenic rupture, and histological demonstration of splenic extramedullary haematopoiesis The portal-phase abdominal computed tomography (CT) scan (A, para-coronal plane; B, sagittal plane) showed massively enlarged, inhomogeneous spleen with multiple, hypodense areas and a prominent laceration at the upper pole (A, red arrow). Subcapsular haematoma (B, red arrow) and signs of peritoneal effusion (A and B, yellow arrows) were also evident. The parenchyma of the spleen presented with expanded and congested red pulp and partly ectatic sinuses, which contained aggregates of cells from the three haematopoietic lineages (C and D: Hematoxylin Eosin, 5× and 20×, respectively). Immunohistochemical staining highlighted mature megakaryocytes (E: CD61, 20×), myeloid (F: myeloperoxidase, 20×) and erythroid (G: CD71, 40×) precursors at different stages of maturation. No morphological alterations and/or cytological specific changes affecting the three haematopoietic lineages were observed, and no blasts were evident by CD34 and CD117 staining (not shown).
See this image and copyright information in PMC

References

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