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Review
. 2020 Dec;139(4):309-318.
doi: 10.1007/s12064-020-00332-4. Epub 2020 Dec 2.

Ingredients for robustness

Affiliations
Review

Ingredients for robustness

Nihat Ay. Theory Biosci. 2020 Dec.

Abstract

A core property of robust systems is given by the invariance of their function against the removal of some of their structural components. This intuition has been formalised in the context of input-output maps, thereby introducing the notion of exclusion independence. We review work on how this formalisation allows us to derive characterisation theorems that provide a basis for the design of robust systems.

Keywords: Interaction order; Knockouts; Neutrality; Robustness.

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Figures

Fig. 1
Fig. 1
An input–output map for the study of robustness
Fig. 2
Fig. 2
Left: unperturbed function. Middle: knockout of node 3. Right: knockout of nodes 2 and 6
Fig. 3
Fig. 3
Optimal function after knockout
Fig. 4
Fig. 4
a A set S in XI; b the connected components of S; c neutrality of the map on the connected components, indicated by colour
Fig. 5
Fig. 5
Structure of a robust map
Fig. 6
Fig. 6
Decomposition of the affinity
Fig. 7
Fig. 7
Removal of the interaction terms ϕ{1,2,3}(x1,x2,x3;y) and ϕ{3,4}(x3,x4;y) as result of the knockout of node 3

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