Placebo-Controlled Trials of Covid-19 Vaccines - Why We Still Need Them

doi:10.1056/NEJMp2033538

. 2021 Jan 14;384(2):e2.

doi: 10.1056/NEJMp2033538. Epub 2020 Dec 2.

Placebo-Controlled Trials of Covid-19 Vaccines - Why We Still Need Them

WHO Ad Hoc Expert Group on the Next Steps for Covid-19 Vaccine Evaluation; Philip R Krause¹, Thomas R Fleming¹, Ira M Longini¹, Richard Peto¹, Valerie Beral¹, Balram Bhargava¹, Alejandro Cravioto¹, Jakob P Cramer¹, Susan S Ellenberg¹, J Peter Figueroa¹, Elizabeth Halloran¹, Ana M Henao-Restrepo¹, Michael J Ryan¹, Myron M Levine¹, Martha Nason¹, Hanna M Nohynek¹, Stanley Plotkin¹, Helen Rees¹, Jerome A Singh¹, Soumya Swaminathan¹

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¹ The affiliations of the members of the WHO Ad Hoc Expert Group on the Next Steps for Covid-19 Vaccine Evaluation are the Office of Vaccines Research and Review, Food and Drug Administration, Silver Spring (P.R.K.), the School of Medicine, University of Maryland (M.M.L.), and Johns Hopkins University (S.P.), Baltimore, and the National Institute of Allergy and Infectious Diseases, Bethesda (M.N.) - all in Maryland; the Department of Biostatistics (T.R.F.), Fred Hutchinson Cancer Research Center (T.R.F., E.H.), University of Washington, Seattle; the Department of Biostatistics, University of Florida, Gainesville (I.M.L.); the Nuffield Department of Population Health, University of Oxford, Oxford, United Kingdom (R.P., V.B.); the Indian Council of Medical Research, New Delhi (B.B.); the Faculty of Medicine of the Universidad Nacional Autónoma de México, Mexico City (A.C.); the Coalition for Epidemic Preparedness Innovations, London (J.P.C.); the University of Pennsylvania, Philadelphia (S.S.E., S.P.); the University of the West Indies, Kingston, Jamaica (J.P.F.); the World Health Organization, Geneva (A.M.H.-R., M.J.R., S.S.); the Department of Health Security, Finnish Institute for Health and Welfare, Helsinki (H.M.N.);and the Wits Reproductive Health and HIV Institute, University of the Witwatersrand, Johannesburg (H.R.), and the Centre for the AIDS Programme of Research in South Africa, Nelson R. Mandela School of Medicine, University of KwaZulu-Natal, Durban (J.S.) - both in South Africa.

PMID: 33264543
DOI: 10.1056/NEJMp2033538

Placebo-Controlled Trials of Covid-19 Vaccines - Why We Still Need Them

WHO Ad Hoc Expert Group on the Next Steps for Covid-19 Vaccine Evaluation et al. N Engl J Med. 2021.

. 2021 Jan 14;384(2):e2.

doi: 10.1056/NEJMp2033538. Epub 2020 Dec 2.

Authors

Affiliation

¹ The affiliations of the members of the WHO Ad Hoc Expert Group on the Next Steps for Covid-19 Vaccine Evaluation are the Office of Vaccines Research and Review, Food and Drug Administration, Silver Spring (P.R.K.), the School of Medicine, University of Maryland (M.M.L.), and Johns Hopkins University (S.P.), Baltimore, and the National Institute of Allergy and Infectious Diseases, Bethesda (M.N.) - all in Maryland; the Department of Biostatistics (T.R.F.), Fred Hutchinson Cancer Research Center (T.R.F., E.H.), University of Washington, Seattle; the Department of Biostatistics, University of Florida, Gainesville (I.M.L.); the Nuffield Department of Population Health, University of Oxford, Oxford, United Kingdom (R.P., V.B.); the Indian Council of Medical Research, New Delhi (B.B.); the Faculty of Medicine of the Universidad Nacional Autónoma de México, Mexico City (A.C.); the Coalition for Epidemic Preparedness Innovations, London (J.P.C.); the University of Pennsylvania, Philadelphia (S.S.E., S.P.); the University of the West Indies, Kingston, Jamaica (J.P.F.); the World Health Organization, Geneva (A.M.H.-R., M.J.R., S.S.); the Department of Health Security, Finnish Institute for Health and Welfare, Helsinki (H.M.N.);and the Wits Reproductive Health and HIV Institute, University of the Witwatersrand, Johannesburg (H.R.), and the Centre for the AIDS Programme of Research in South Africa, Nelson R. Mandela School of Medicine, University of KwaZulu-Natal, Durban (J.S.) - both in South Africa.

PMID: 33264543
DOI: 10.1056/NEJMp2033538

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Double standards redux.
Macklin R. Macklin R. Indian J Med Ethics. 2021 Apr-Jun;VI(2):1-7. doi: 10.20529/IJME.2021.021. Indian J Med Ethics. 2021. PMID: 33908355

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Placebo-Controlled Trials of Covid-19 Vaccines - Why We Still Need Them

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Placebo-Controlled Trials of Covid-19 Vaccines - Why We Still Need Them

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