Skip to main page content
U.S. flag

An official website of the United States government

Dot gov

The .gov means it’s official.
Federal government websites often end in .gov or .mil. Before sharing sensitive information, make sure you’re on a federal government site.

Https

The site is secure.
The https:// ensures that you are connecting to the official website and that any information you provide is encrypted and transmitted securely.

Access keys NCBI Homepage MyNCBI Homepage Main Content Main Navigation
. 1987 Oct-Dec;5(4):317-21.

Scleroderma: DR antigens, autoantibodies and clinical manifestations

G S Alarcón  1 , G A McCarty, P Lanyon, R M Phillips, R T Acton, B O Barger
Affiliations
  • PMID: 3326691

Scleroderma: DR antigens, autoantibodies and clinical manifestations

G S Alarcón et al. Clin Exp Rheumatol. 1987 Oct-Dec.

Abstract

The relationship between anticentromere antibodies (ACA), antitopoisomerase I or Scleroderma 70 (Scl-70) antibodies, HLA-DR antigens, and clinical manifestations of scleroderma were examined in 51 patients defined by ARA criteria. No association between a given HLA-DR antigen and either ACA or anti-Scl-70 was found. Statistically significant associations were noted for patients with ACA who had a lower frequency of arthritis and longer disease duration; anti-Scl-70 patients were more likely to be males with a higher frequency of pulmonary, cardiac and sicca symptoms.

PubMed Disclaimer

Publication types