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. 2020 Dec 2;29(158):200289.
doi: 10.1183/16000617.0289-2020. Print 2020 Dec 31.

Current developments and future directions in COPD

Alexander G Mathioudakis  1   2 , Lowie E G W Vanfleteren  3 , Lies Lahousse  4 , Andrew Higham  5   2 , James P Allinson  6 , Carolina Gotera  7 , Dina Visca  8   9 , Dave Singh  5   2   10 , Antonio Spanevello  8   9
Affiliations

Current developments and future directions in COPD

Alexander G Mathioudakis et al. Eur Respir Rev. .

Abstract

The European Respiratory Society journals publish respiratory research and policy documents of the highest quality, offering a platform for the exchange and promotion of scientific knowledge. In this article, focusing on COPD, the third leading cause of death globally, we summarise novel research highlights focusing on the disease's underlying mechanisms, epidemiology and management, with the aim to inform and inspire respiratory clinicians and researchers.

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Conflict of interest statement

Conflict of interest: A.G. Mathioudakis has nothing to disclose. Conflict of interest: L.E.G.W. Vanfleteren reports grants and personal fees from AstraZeneca, and personal fees from Novartis, GSK, Chiesi, Menarini, Pulmonx, Resmed, Boehringer, Verona Pharma and AGA Linde outside the submitted work. Conflict of interest: L. Lahousse reports Society awards sponsored by AstraZeneca and Chiesi; and has provided expert consultation for Boehringer Ingelheim GmbH and Novartis, outside the submitted work. Conflict of interest: A. Higham reports personal fees from Chiesi Pharmaceuticals, outside the submitted work. Conflict of interest: J.P. Allinson reports personal fees from Pulmonx, and non-financial support from GSK and Boehringer Ingelheim, outside the submitted work. Conflict of interest: C. Gotera has nothing to disclose. Conflict of interest: D. Visca has nothing to disclose. Conflict of interest: D. Singh reports grants and personal fees from AstraZeneca, Boehringer Ingelheim, Chiesi, GlaxoSmithKline, Glenmark, Menarini, Mundipharma, Novartis, Pfizer, Pulmatrix, Therevance and Verona, and personal fees from Cipla, Genentech and Peptinnovate, outside the submitted work. Conflict of interest: A. Spanevello has nothing to disclose.

Figures

FIGURE 1
FIGURE 1
Basic mechanisms. Schematic diagram illustrating some of the studies published in European Respiratory Society journals which provide important insights into the basic mechanisms of COPD pathophysiology. ACE2: angiotensin converting enzyme 2; BMI: body mass index; BMP4: bone morphogenetic protein 4; IL-13: interleukin-13; ILC2: type 2 innate lymphoid cell; MMP-12: matrix metalloproteinase-12; T2: type 2; Th2: T-helper 2 lymphocytes.
FIGURE 2
FIGURE 2
Barriers and enablers to pulmonary rehabilitation referral and uptake. PR: pulmonary rehabilitation; GP: general practitioner. Reproduced from [79] with permission.
See this image and copyright information in PMC

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