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Comment
. 2020 Dec 22;117(51):32192-32194.
doi: 10.1073/pnas.2022205117. Epub 2020 Dec 2.

Decoding DMD transcriptional networks using single-nucleus RNA sequencing

Daniel J Garry  1   2 , Satyabrata Das  3 , Wuming Gong  3
Affiliations
Comment

Decoding DMD transcriptional networks using single-nucleus RNA sequencing

Daniel J Garry et al. Proc Natl Acad Sci U S A. .
No abstract available

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Conflict of interest statement

Competing interest statement: D.J.G. is a cofounder of NorthStar Genomics.

Figures

Fig. 1.
Fig. 1.
Decoding the molecular mechanisms of DMD pathogenesis utilizing snRNA-seq. This figure schematizes the discoveries outlined in Chemello et al. (7) with the newly generated DMD mouse model (ΔEx51) and the transcriptomic analysis of isolated nuclei from skeletal muscle cells. The snRNA-seq analysis was used to discover factors and pathways underlying DMD pathogenesis from previously unrecognized cell clusters. These results in combination with other databases provide a platform for developing new therapeutic interventions as well as an enhanced understanding of the gene-regulatory networks involved in muscle biology and DMD.
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