Skip to main page content
U.S. flag

An official website of the United States government

Dot gov

The .gov means it’s official.
Federal government websites often end in .gov or .mil. Before sharing sensitive information, make sure you’re on a federal government site.

Https

The site is secure.
The https:// ensures that you are connecting to the official website and that any information you provide is encrypted and transmitted securely.

Access keys NCBI Homepage MyNCBI Homepage Main Content Main Navigation
. 2021 Feb 8;16(2):287-289.
doi: 10.2215/CJN.12100720. Epub 2020 Dec 2.

Effect of Sickle Cell Trait and APOL1 Genotype on the Association of Soluble uPAR with Kidney Function Measures in Black Americans

Alexander P Reiner  1 , Laura M Raffield  2 , Nora Franceschini  3 , Paul L Auer  4 , Ethan M Lange  5 , Deborah A Nickerson  6 , Neil A Zakai  7   8 , Adolfo Correa  9 , Nels Olson  8 ; National Heart, Lung, and Blood Institute Trans-Omics for Precision Medicine Consortium; Natinal Heart, Lung, and Blood Institute Trans-Omics for Precision Medicine Consortium
Collaborators, Affiliations

Effect of Sickle Cell Trait and APOL1 Genotype on the Association of Soluble uPAR with Kidney Function Measures in Black Americans

Alexander P Reiner et al. Clin J Am Soc Nephrol. .
No abstract available

Keywords: chronic kidney disease; clinical epidemiology; genetic renal disease; sickle cell trait.

PubMed Disclaimer

References

    1. Hamie L, Daoud G, Nemer G, Nammour T, El Chediak A, Uthman IW, Kibbi AG, Eid A, Kurban M: SuPAR, an emerging biomarker in kidney and inflammatory diseases. Postgrad Med J 94: 517–524, 2018 - PubMed
    1. Hayek SS, Koh KH, Grams ME, Wei C, Ko YA, Li J, Samelko B, Lee H, Dande RR, Lee HW, Hahm E, Peev V, Tracy M, Tardi NJ, Gupta V, Altintas MM, Garborcauskas G, Stojanovic N, Winkler CA, Lipkowitz MS, Tin A, Inker LA, Levey AS, Zeier M, Freedman BI, Kopp JB, Skorecki K, Coresh J, Quyyumi AA, Sever S, Reiser J: A tripartite complex of suPAR, APOL1 risk variants and αvβ3 integrin on podocytes mediates chronic kidney disease. Nat Med 23: 945–953, 2017 - PMC - PubMed
    1. Luo S, Coresh J, Tin A, Rebholz CM, Chen TK, Hayek SS, Tracy M, Lipkowitz MS, Appel LJ, Levey AS, Inker LA, Reiser J, Grams ME: Soluble urokinase-type plasminogen activator receptor in Black Americans with CKD. Clin J Am Soc Nephrol 13: 1013–1021, 2018 - PMC - PubMed
    1. Pecker LH, Naik RP: The current state of sickle cell trait: Implications for reproductive and genetic counseling. Blood 132: 2331–2338, 2018 - PMC - PubMed
    1. Saraf SL, Sysol JR, Susma A, Setty S, Zhang X, Gudehithlu KP, Arruda JAL, Singh AK, Machado RF, Gordeuk VR: Progressive glomerular and tubular damage in sickle cell trait and sickle cell anemia mouse models. Transl Res 197: 1–11, 2018 - PMC - PubMed

Publication types

MeSH terms