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Comment
. 2021 Feb 1;27(3):662-664.
doi: 10.1158/1078-0432.CCR-20-4067. Epub 2020 Dec 2.

News FLASH-RT: To Treat GBM and Spare Cognition, Fraction Size and Total Dose Matter

Christina C Huang  1 , Marc S Mendonca  2   3
Affiliations
Comment

News FLASH-RT: To Treat GBM and Spare Cognition, Fraction Size and Total Dose Matter

Christina C Huang et al. Clin Cancer Res. .

Abstract

Data indicate that ultrahigh dose rate (>106 Gy/second) FLASH radiotherapy (FLASH-RT) delivery of radiation reduces normal tissue damage without compromising tumor response. Orthotopic glioblastoma mouse studies now demonstrate that radiation fraction size, total dose, and number of fractions are critical parameters for FLASH-RT cognitive sparing without compromising tumor response.See related article by Montay-Gruel et al., p. 775.

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References

    1. Montay-Gruel P, Acharya MM, Jorge PG, Petit B, Petridis IG, Fuchs P, et al. Hypo-fractionated FLASH-RT as an effective treatment against glioblastoma that reduces neurocognitive side effects in mice. Clin Cancer Res. 2021;27:775–84.
    1. Folkert MR, Timmerman RD. Stereotactic ablative body radiosurgery (SABR) or stereotactic body radiation therapy (SBRT). Adv Drug Deliv Rev. 2017;109:3–14.
    1. Marenco-Hillembrand L, Wijesekera O, Suarez-Meade P, Mampre D, Jackson C, Peterson J, et al. Trends in glioblastoma: outcomes over time and type of intervention: a systematic evidence based analysis. J Neurooncol. 2020;147:297–307.
    1. Montay-Gruel P, Petersson K, Jaccard M, Boivin G, Germond JF, Petit B, et al. Irradiation in a flash: unique sparing of memory in mice after whole brain irradiation with dose rates above 100 Gy/s. Radiother Oncol. 2017;124:365–9.
    1. Bourhis J, Montay-Gruel P, Goncalves Jorge P, Bailat C, Petit B, Ollivier J, et al. Clinical translation of FLASH radiotherapy: why and how?. Radiother Oncol. 2019;139:11–7.

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