Skip to main page content
U.S. flag

An official website of the United States government

Dot gov

The .gov means it’s official.
Federal government websites often end in .gov or .mil. Before sharing sensitive information, make sure you’re on a federal government site.

Https

The site is secure.
The https:// ensures that you are connecting to the official website and that any information you provide is encrypted and transmitted securely.

Access keys NCBI Homepage MyNCBI Homepage Main Content Main Navigation
. 2021 Jan;14(1):14.
doi: 10.3892/br.2020.1390. Epub 2020 Nov 17.

Associations of the MTHFR rs1801133 polymorphism with gastric cancer risk in the Chinese Han population

Zhiqiang Han  1 , Huaming Sheng  2   3 , Qiuzhi Gao  4 , Yu Fan  5 , Xiang Xie  6
Affiliations

Associations of the MTHFR rs1801133 polymorphism with gastric cancer risk in the Chinese Han population

Zhiqiang Han et al. Biomed Rep. 2021 Jan.

Abstract

In recent years, increasing evidence has implicated the importance of mutations in the MTHFR gene in the risk of gastric cancer risk. A single nucleotide polymorphism (SNP) in the MTHFR gene (rs1801133) may serve a critical role in gastric cancer. A hospital-based case-controlled study was performed to assess the risk of the rs1801133 polymorphism on gastric cancer. A total of 307 patients with gastric cancer and 560 patients in the control group were recruited. Genomic DNA was extracted from peripheral blood and genotyped for rs1801133 using the ligase detection reaction. The relationship between rs1801133 and gastric cancer risk was evaluated by unconditional logistical regression analysis. The rs1801133-TT genotype was associated with a borderline significantly decreased risk of gastric cancer [(TT vs. CC, adjusted odds ratio (OR)=0.54, 95% confidence intervals (CI)=0.35-0.83; P=0.006; CT vs. CC, adjusted OR=0.59, 95% CI=0.44-0.79, P<0.001; and TT/CT vs. CC, adjusted OR=0.61, 95% CI=0.44-0.83, P=0.001), and further analysis showed the relationship was evident amongst older patients and patients who never drank alcohol. The C>T mutation at rs1801133 of the MTHFR gene was associated with a decreased risk of gastric cancer in older individuals and those who never drink.

Keywords: MTHFR rs1801133; gastric cancer; polymorphism; risk.

PubMed Disclaimer

Similar articles

See all similar articles

Cited by

See all "Cited by" articles

References

    1. Sun L, Wang Q, Chen B, Zhao Y, Shen B, Wang H, Xu J, Zhu M, Zhao X, Xu C, et al. Gastric cancer mesenchymal stem cells derived IL-8 induces PD-L1 expression in gastric cancer cells via STAT3/mTOR-c-Myc signal axis. Cell Death Dis. 2018;9(928) doi: 10.1038/s41419-018-0988-9. - DOI - PMC - PubMed
    1. Potrc S, Ivanecz A, Krebs B, Marolt U, Iljevec B, Jagric T. Outcomes of the surgical treatment for adenocarcinoma of the cardia-single institution experience. Radiol Oncol. 2018;52:65–74. doi: 10.1515/raon-2017-0039. - DOI - PMC - PubMed
    1. Xin J, Wu Y, Wang X, Li S, Chu H, Wang M, Du M, Zhang Z. A transcriptomic study for identifying cardia- and non-cardia-specific gastric cancer prognostic factors using genetic algorithm-based methods. J Cell Mol Med. 2020;24:9457–9465. doi: 10.1111/jcmm.15618. - DOI - PMC - PubMed
    1. Nguyen TH, Mallepally N, Hammad T, Liu Y, Thrift AP, El-Serag HB, Tan MC. Prevalence of Helicobacter pylori positive non-cardia gastric adenocarcinoma is low and decreasing in a US population. Dig Dis Sci. 2020;65:2403–2411. - PMC - PubMed
    1. Zhang X, Bai Z, Chen B, Feng J, Yan F, Jiang Z, Zhong Y, Wu J, Cheng L, Lu Z, et al. Polymorphism of methylenetetrahydrofolate reductase gene is associated with response to fluorouracil-based chemotherapy in Chinese patients with gastric cancer. Chin Med J (Engl) 2014;127:3562–3567. - PubMed

LinkOut - more resources