Characteristics associated with COVID-19 or other respiratory viruses' infections at a single-center emergency department

doi:10.1371/journal.pone.0243261

. 2020 Dec 3;15(12):e0243261.

doi: 10.1371/journal.pone.0243261. eCollection 2020.

Characteristics associated with COVID-19 or other respiratory viruses' infections at a single-center emergency department

Donia Bouzid^{1

2}, Jimmy Mullaert^{1

3}, Quentin Le Hingrat^{1

4}, Odile Laurent², Xavier Duval^{1

4}, Xavier Lescure^{1

5}, Jean-François Timsit^{1

6}, Diane Descamps^{1

4}, Philippe Montravers⁷, Christophe Choquet², Jean-Christophe Lucet^{1

8}, Enrique Casalino^{1

2}, Benoit Visseaux^{1

4}; ED influenza study group

Affiliations

¹ INSERM, IAME, Université de Paris, Paris, France.
² AP-HP Nord, Emergency Department, Bichat-Claude Bernard University Hospital, Paris, France.
³ AP-HP Nord, Department of Epidemiology, Biostatistics and Clinical Research, Bichat-Claude Bernard University Hospital, Paris, France.
⁴ AP-HP Nord, Virology Department, Bichat-Claude Bernard University Hospital, Paris, France.
⁵ AP-HP Nord, Infectious Diseases Department, Bichat-Claude Bernard University Hospital, Paris, France.
⁶ AP-HP Nord, Medical and Infectious Diseases Intensive Care Unit, Bichat-Claude Bernard University Hospital, Paris, France.
⁷ AP-HP Nord, Department of Anesthesiology and Critical Care Medicine, Bichat-Claude Bernard University Hospital, Paris, France.
⁸ AP-HP Nord, Infection Control Unit, Bichat-Claude Bernard University Hospital, Paris, France.

PMID: 33270790
PMCID: PMC7714208
DOI: 10.1371/journal.pone.0243261

Characteristics associated with COVID-19 or other respiratory viruses' infections at a single-center emergency department

Donia Bouzid et al. PLoS One. 2020.

. 2020 Dec 3;15(12):e0243261.

doi: 10.1371/journal.pone.0243261. eCollection 2020.

Authors

Affiliations

¹ INSERM, IAME, Université de Paris, Paris, France.
² AP-HP Nord, Emergency Department, Bichat-Claude Bernard University Hospital, Paris, France.
³ AP-HP Nord, Department of Epidemiology, Biostatistics and Clinical Research, Bichat-Claude Bernard University Hospital, Paris, France.
⁴ AP-HP Nord, Virology Department, Bichat-Claude Bernard University Hospital, Paris, France.
⁵ AP-HP Nord, Infectious Diseases Department, Bichat-Claude Bernard University Hospital, Paris, France.
⁶ AP-HP Nord, Medical and Infectious Diseases Intensive Care Unit, Bichat-Claude Bernard University Hospital, Paris, France.
⁷ AP-HP Nord, Department of Anesthesiology and Critical Care Medicine, Bichat-Claude Bernard University Hospital, Paris, France.
⁸ AP-HP Nord, Infection Control Unit, Bichat-Claude Bernard University Hospital, Paris, France.

PMID: 33270790
PMCID: PMC7714208
DOI: 10.1371/journal.pone.0243261

Erratum in

Correction: Characteristics associated with COVID-19 or other respiratory viruses' infections at a single-center emergency department.
Bouzid D, Mullaert J, Le Hingrat Q, Laurent O, Duval X, Lescure X, Timsit JF, Descamps D, Montravers P, Choquet C, Lucet JC, Casalino E, Visseaux B; ED influenza study group. Bouzid D, et al. PLoS One. 2021 Jan 27;16(1):e0246458. doi: 10.1371/journal.pone.0246458. eCollection 2021. PLoS One. 2021. PMID: 33503069 Free PMC article.

Abstract

Background: Rapid identification of patients with high suspicion of COVID-19 will become a challenge with the co-circulation of multiple respiratory viruses (RVs). We have identified clinical or biological characteristics to help distinguish SARS-CoV-2 from other RVs.

Methods: We used a prospective cohort including all consecutive patients admitted through the emergency department's (ED) and presenting respiratory symptoms from November 2019 to April 2020. Patients were tested for RV using multiplex polymerase chain reaction (mPCR) and SARS-CoV-2 RT-PCR.

Results: 203/508 patients were positive for an RV during the non-SARS-CoV-2 epidemic period (November to February), and 268/596 patients were SARS-CoV-2 positive during the SARS-CoV-2 epidemic (March to April). Younger age, male gender, fever, absence of expectoration and absence of chronic lung disease were statistically associated with SARS-CoV-2 detection. Combining these variables allowed for the distinguishing of SARS-CoV-2 infections with 83, 65, 75 and 76% sensitivity, specificity, PPV and NPV, respectively.

Conclusion: Patients' characteristics associated with a positive PCR are common between SARS-CoV-2 and other RVs, but a simple discrimination of strong SARS-CoV-2 suspicion with a limited set of clinical features seems possible. Such scoring could be useful but has to be prospectively evaluated and will not eliminate the need for rapid PCR assays.

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Conflict of interest statement

DB and BV declare having received past personal fees and grant from Qiagen. All the others declare having no conflict of interest. This does not alter our adherence to PLOS ONE policies on sharing data and materials.

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References

1. Li Q, Guan X, Wu P, Wang X, Zhou L, Tong Y, et al. Early Transmission Dynamics in Wuhan, China, of Novel Coronavirus–Infected Pneumonia. New England Journal of Medicine. 2020. January 29;0(0):null. 10.1056/NEJMoa2001316 - DOI - PMC - PubMed
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1. Lescure F-X, Bouadma L, Nguyen D, Parisey M, Wicky P-H, Behillil S, et al. Clinical and virological data of the first cases of COVID-19 in Europe: a case series. The Lancet Infectious Diseases. 2020. June 1;20(6):697–706. 10.1016/S1473-3099(20)30200-0 - DOI - PMC - PubMed
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[1] Li Q, Guan X, Wu P, Wang X, Zhou L, Tong Y, et al. Early Transmission Dynamics in Wuhan, China, of Novel Coronavirus–Infected Pneumonia. New England Journal of Medicine. 2020. January 29;0(0):null. 10.1056/NEJMoa2001316 - DOI - PMC - PubMed

[2] Li Q, Guan X, Wu P, Wang X, Zhou L, Tong Y, et al. Early Transmission Dynamics in Wuhan, China, of Novel Coronavirus–Infected Pneumonia. New England Journal of Medicine. 2020. January 29;0(0):null. 10.1056/NEJMoa2001316 - DOI - PMC - PubMed

[3] WHO Coronavirus Disease (COVID-19) Dashboard [Internet]. [cited 2020 Jun 29]. Available from: https://covid19.who.int

[4] WHO Coronavirus Disease (COVID-19) Dashboard [Internet]. [cited 2020 Jun 29]. Available from: https://covid19.who.int

[5] Lescure F-X, Bouadma L, Nguyen D, Parisey M, Wicky P-H, Behillil S, et al. Clinical and virological data of the first cases of COVID-19 in Europe: a case series. The Lancet Infectious Diseases. 2020. June 1;20(6):697–706. 10.1016/S1473-3099(20)30200-0 - DOI - PMC - PubMed

[6] Lescure F-X, Bouadma L, Nguyen D, Parisey M, Wicky P-H, Behillil S, et al. Clinical and virological data of the first cases of COVID-19 in Europe: a case series. The Lancet Infectious Diseases. 2020. June 1;20(6):697–706. 10.1016/S1473-3099(20)30200-0 - DOI - PMC - PubMed

[7] COVID-19 situation update worldwide, as of 9 July 2020 [Internet]. [cited 2020 Jul 10]. Available from: https://www.ecdc.europa.eu/en/geographical-distribution-2019-ncov-cases

[8] COVID-19 situation update worldwide, as of 9 July 2020 [Internet]. [cited 2020 Jul 10]. Available from: https://www.ecdc.europa.eu/en/geographical-distribution-2019-ncov-cases

[9] Li Y, Reeves RM, Wang X, Bassat Q, Brooks WA, Cohen C, et al. Global patterns in monthly activity of influenza virus, respiratory syncytial virus, parainfluenza virus, and metapneumovirus: a systematic analysis. Lancet Glob Health. 2019;7(8):e1031–45. 10.1016/S2214-109X(19)30264-5 - DOI - PubMed

[10] Li Y, Reeves RM, Wang X, Bassat Q, Brooks WA, Cohen C, et al. Global patterns in monthly activity of influenza virus, respiratory syncytial virus, parainfluenza virus, and metapneumovirus: a systematic analysis. Lancet Glob Health. 2019;7(8):e1031–45. 10.1016/S2214-109X(19)30264-5 - DOI - PubMed

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Characteristics associated with COVID-19 or other respiratory viruses' infections at a single-center emergency department

Affiliations

Characteristics associated with COVID-19 or other respiratory viruses' infections at a single-center emergency department

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Affiliations

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