[Effect of corinfar on the course of angina pectoris and indices of carbohydrate metabolism in relation to the type of glucose tolerance]

Abstract

Nifedipine influence on a clinical course of angina pectoris, some indices of hemodynamics, glucose and insulin was studied in 39 male patients suffering from coronary heart disease (CHD) with different glucose tolerance. In CHD patients with normal glucose tolerance (NGT) nifedipine therapy did not cause any considerable changes in the blood levels of glucose and insulin whereas in patients with lowered glucose tolerance (LGT) a hypoglycemic effect of the drug and an increase in the level of insulin were noted during therapy. An increase in physical exercise tolerance, a decrease in the frequency of anginal attacks, and a decrease in the number of nitroglycerin tablets administered by CHD patients with LGT per week were significant. The study showed that nifedipine was indicated for CHD patients with LGT.