Incidence and Outcome of Aneurysmal Subarachnoid Hemorrhage: The Swiss Study on Subarachnoid Hemorrhage (Swiss SOS)

Bawarjan Schatlo^{1

2

3}, Christian Fung^{4

5}, Martin N Stienen⁶, Ali R Fathi⁷, Javier Fandino², Nicolas R Smoll⁸, Daniel Zumofen⁹, Roy Thomas Daniel¹⁰, Jan-Karl Burkhardt⁶, David Bervini⁴, Serge Marbacher², Michael Reinert¹¹, Donato D Alonzo², Peter Ahlborn¹², Vitor Mendes Pereira¹³, Michel Roethlisberger⁹, Martin Seule¹², Hassen Kerkeni¹⁴, Luca Remonda¹⁵, Astrid Weyerbrock¹², Kerstin Woernle², Alice Venier¹¹, Fabienne Perren¹⁶, Martin Sailer⁹, Thomas Robert¹¹, Veit Rohde³, Daniel Schöni⁴, Johannes Goldberg⁴, Edin Nevzati¹⁷, Michael Diepers¹⁵, Jan Gralla¹⁸, Werner Z'Graggen¹⁸, Daniele Starnoni¹⁰, Christoph Woernle⁶, Nicolai Maldaner⁶, Zsolt Kulcsar¹⁹, Khaled Mostaguir²⁰, Rodolfo Maduri¹⁰, Christian Eisenring⁴, René Bernays⁶, Andrea Ferrari¹², Hiroki Dan-Ura², Sina Finkenstädt⁶, Yvan Gasche²¹, Asita Sarrafzadeh¹, Stephan M Jakob²², Marco Corniola¹, Fabian Baumann¹⁷, Luca Regli⁶, Marc Levivier¹⁰, Gerhard Hildebrandt¹², Hans Landolt², Luigi Mariani⁹, Raphael Guzman⁹, Jürgen Beck^{4

5}, Andreas Raabe⁴, Emanuela Keller²³, Philippe Bijlenga¹, Karl Schaller¹

Affiliations

¹ Neurosurgery (B.S., A.S., M.C., P.B., K.S.), University Hospital Geneva, Switzerland.
² Neurosurgery (B.S., J.F., S.M., D.D., K.W., H.D.U., H.L.), Kantonsspital Aarau Switzerland.
³ Neurosurgery, University Hospital Göttingen Germany (B.S., V.R.).
⁴ Neurosurgery (C.F., D.B., D. Schöni, J. Goldberg, C.E., J.B., A.R.), University Hospital Bern Switzerland.
⁵ Department of Neurosurgery, Faculty of Medicine, Medical Center, University of Freiburg, Germany (J.B., C.F.).
⁶ Neurosurgery (M.N.S., J.-K.B., C.W., N.M., R.B., S.F., L.R.), University Hospital Zürich Switzerland.
⁷ Neurosurgery, Hirslanden Klinik Aarau Switzerland (A.R.F.).
⁸ School of Population and Global, University of Melbourne Australia (N.R.S.).
⁹ Neurosurgery, University Hospital Basel Switzerland (D.Z., M. Roethlisberger, M. Sailer, L.M., R.G.).
¹⁰ Neurosurgery, University Hospital Lausanne Switzerland (R.T.D., D. Starnoni, R.M., M.L.).
¹¹ Neurosurgery, Ospedale Civico Lugano Switzerland (M. Reinert, A.V., T.R.).
¹² Neurosurgery, Kantonsspital St. Gallen Switzerland (P.A., M. Seule, A.W., A.F., G.H.).
¹³ Neuroradiology, University of Toronto Canada (V.M.P.).
¹⁴ Neurology (H.K.), Kantonsspital Aarau Switzerland.
¹⁵ Neuroradiology (L.R., M.D.), Kantonsspital Aarau Switzerland.
¹⁶ Neurology (F.P.), University Hospital Geneva, Switzerland.
¹⁷ Neurosurgery, Kantonsspital Luzern Switzerland (E.N., F.B.).
¹⁸ Neuroradiology (J. Gralla, W.Z.), University Hospital Bern Switzerland.
¹⁹ Department of Neuroradiology, University Hospital Zürich, Switzerland (Z.K.).
²⁰ Clinical Research Centre, (K.M.), University Hospital Geneva, Switzerland.
²¹ Intensive Care Medicine (Y.G.), University Hospital Geneva, Switzerland.
²² Intensive Care Medicine (S.M.J.), University Hospital Bern Switzerland.
²³ Intensive Care Medicine (E.K.), University Hospital Zürich Switzerland.

PMID: 33272133
DOI: 10.1161/STROKEAHA.120.029538

Incidence and Outcome of Aneurysmal Subarachnoid Hemorrhage: The Swiss Study on Subarachnoid Hemorrhage (Swiss SOS)

Bawarjan Schatlo et al. Stroke. 2021 Jan.

. 2021 Jan;52(1):344-347.

doi: 10.1161/STROKEAHA.120.029538. Epub 2020 Dec 4.

Authors

Affiliations

¹ Neurosurgery (B.S., A.S., M.C., P.B., K.S.), University Hospital Geneva, Switzerland.
² Neurosurgery (B.S., J.F., S.M., D.D., K.W., H.D.U., H.L.), Kantonsspital Aarau Switzerland.
³ Neurosurgery, University Hospital Göttingen Germany (B.S., V.R.).
⁴ Neurosurgery (C.F., D.B., D. Schöni, J. Goldberg, C.E., J.B., A.R.), University Hospital Bern Switzerland.
⁵ Department of Neurosurgery, Faculty of Medicine, Medical Center, University of Freiburg, Germany (J.B., C.F.).
⁶ Neurosurgery (M.N.S., J.-K.B., C.W., N.M., R.B., S.F., L.R.), University Hospital Zürich Switzerland.
⁷ Neurosurgery, Hirslanden Klinik Aarau Switzerland (A.R.F.).
⁸ School of Population and Global, University of Melbourne Australia (N.R.S.).
⁹ Neurosurgery, University Hospital Basel Switzerland (D.Z., M. Roethlisberger, M. Sailer, L.M., R.G.).
¹⁰ Neurosurgery, University Hospital Lausanne Switzerland (R.T.D., D. Starnoni, R.M., M.L.).
¹¹ Neurosurgery, Ospedale Civico Lugano Switzerland (M. Reinert, A.V., T.R.).
¹² Neurosurgery, Kantonsspital St. Gallen Switzerland (P.A., M. Seule, A.W., A.F., G.H.).
¹³ Neuroradiology, University of Toronto Canada (V.M.P.).
¹⁴ Neurology (H.K.), Kantonsspital Aarau Switzerland.
¹⁵ Neuroradiology (L.R., M.D.), Kantonsspital Aarau Switzerland.
¹⁶ Neurology (F.P.), University Hospital Geneva, Switzerland.
¹⁷ Neurosurgery, Kantonsspital Luzern Switzerland (E.N., F.B.).
¹⁸ Neuroradiology (J. Gralla, W.Z.), University Hospital Bern Switzerland.
¹⁹ Department of Neuroradiology, University Hospital Zürich, Switzerland (Z.K.).
²⁰ Clinical Research Centre, (K.M.), University Hospital Geneva, Switzerland.
²¹ Intensive Care Medicine (Y.G.), University Hospital Geneva, Switzerland.
²² Intensive Care Medicine (S.M.J.), University Hospital Bern Switzerland.
²³ Intensive Care Medicine (E.K.), University Hospital Zürich Switzerland.

PMID: 33272133
DOI: 10.1161/STROKEAHA.120.029538

Abstract

Background and purpose: The purpose of this study was to assess nationwide incidence and outcomes of aneurysmal subarachnoid hemorrhage (aSAH). The Swiss SOS (Swiss Study on Subarachnoid Hemorrhage) was established in 2008 and offers the unique opportunity to provide this data from the point of care on a nationwide level.

Methods: All patients with confirmed aneurysmal subarachnoid hemorrhage admitted between January 1, 2009 and December 31, 2014, within Switzerland were recorded in a prospective registry. Incidence rates were calculated based on time-matched population data. Admission parameters and outcomes at discharge and at 1 year were recorded.

Results: We recorded data of 1787 consecutive patients. The incidence of aneurysmal subarachnoid hemorrhage in Switzerland was 3.7 per 100 000 persons/y. The number of female patients was 1170 (65.5%). With a follow-up rate of 91.3% at 1 year, 1042 patients (58.8%) led an independent life according to the modified Rankin Scale (0-2). About 1 in 10 patients survived in a dependent state (modified Rankin Scale, 3-5; n=185; 10.4%). Case fatality was 20.1% (n=356) at discharge and 22.1% (n=391) after 1 year.

Conclusions: The current incidence of aneurysmal subarachnoid hemorrhage in Switzerland is lower than expected and an indication of a global trend toward decreasing admissions for ruptured intracranial aneurysms. Registration: URL: https://www.clinicaltrials.gov. Unique identifier: NCT03245866.

Keywords: Switzerland; incidence; intracranial aneurysm; outcome; patients; stroke; subarachnoid hemorrhage.

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Incidence and Outcome of Aneurysmal Subarachnoid Hemorrhage: The Swiss Study on Subarachnoid Hemorrhage (Swiss SOS)

Affiliations

Incidence and Outcome of Aneurysmal Subarachnoid Hemorrhage: The Swiss Study on Subarachnoid Hemorrhage (Swiss SOS)

Authors

Affiliations

Abstract

MeSH terms

Associated data

LinkOut - more resources

Full Text Sources

Other Literature Sources

Medical