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. 2020 Nov 25:2020:10.17912/micropub.biology.000337.
doi: 10.17912/micropub.biology.000337.

CWN-2/Wnt regulates SMDD axonal development

Tessa Sherry  1   2 , Hannah R Nicholas  2 , Roger Pocock  1
Affiliations

CWN-2/Wnt regulates SMDD axonal development

Tessa Sherry et al. MicroPubl Biol. .
No abstract available

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Figures

Figure 1. The Wnt ligand CWN-2 and Ror receptor CAM-1 control SMDD axonal development
Figure 1. The Wnt ligand CWN-2 and Ror receptor CAM-1 control SMDD axonal development
(A-B) Schematic of a wild-type (A) and defective (B) SMDD axon where the axon is not visible in the sublateral nerve cord. (C) Quantification of the SMDD axonal phenotype in the cwn-2(ok895) mutant and rescue using three independent transgenic lines expressing Pctbp-1::cwn-2 cDNA (#1-3). (D) Quantification of the SMDD axonal phenotype of mutant alleles for Wnt receptors LIN-17, CFZ-2, MIG-1,LIN-18, CAM-1 and MOM-5. SMDD development was analyzed with either the rhIs4(Pglr-1::GFP) or Pctbp-1a::GFP reporter and scored defective if the SMDD axon was not visible in the sublateral nerve cord. Data presented as mean ± S.E.M (bar) of at least three biological replicates (black dots) by one-way ANOVA with Tukey’s correction. n>60 axons per bar. n.s. – not significant.
See this image and copyright information in PMC

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