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. 2020 Nov 12:2020:10.17912/micropub.biology.000325.
doi: 10.17912/micropub.biology.000325.

Neuronal expression of Ca2+ oscillation initiator is linked to rapid neonatal growth in mice

Woojin Kang  1 , Kenji Yamatoya  2 , Kenji Miyado  1 , Mami Miyado  3 , Yoshitaka Miyamoto  1
Affiliations

Neuronal expression of Ca2+ oscillation initiator is linked to rapid neonatal growth in mice

Woojin Kang et al. MicroPubl Biol. .
No abstract available

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Figures

Figure 1. Neuronal extra-mitochondrial citrate synthase (eCs) expression and retarded neonatal growth in eCs-deficient (KO) male mice
Figure 1. Neuronal extra-mitochondrial citrate synthase (eCs) expression and retarded neonatal growth in eCs-deficient (KO) male mice
(A) Cooperative function of two citrate synthases, CS and eCS. (B) Growth curve of wild-type (WT) and eCs-KO mice. Ten mice from each genotype were weighed once a week. Dotted box: eCs-KO mice with significantly reduced weight. Arrow: eCs-KO mice brains highlighted with LacZ staining. Values are expressed as mean ± standard error of the mean. * p < 0.0001. (C) The eCs expression in adult mouse brains (9-week-old males). In the eCs-null allele, eCs-promoter drives the expression of the LacZ reporter gene. The LacZ-stained brain was viewed from dorsal (upper panel) and ventral (lower panel) surfaces from the same individual male. In the cerebellum, visualization of β-galactosidase activity in KO adult mice showed the eCs expression in a single cell layer lined inside the cerebellum, presumably the Purkinje cell layer. Dotted box in the inset: enlarged region. Scale bars: 5 mm.
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