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. 2021 Mar;89(3):511-519.
doi: 10.1002/ana.25978. Epub 2020 Dec 15.

Time from I.V. Thrombolysis to Thrombectomy and Outcome in Acute Ischemic Stroke

François Zhu  1   2 , Maxime Gauberti  3   4 , Gaultier Marnat  5 , Romain Bourcier  6 , Maéva Kyheng  7 , Julien Labreuche  7 , Igor Sibon  8 , Cyril Dargazanli  9 , Caroline Arquizan  10 , René Anxionnat  1   2 , Gérard Audibert  11 , Mikaël Mazighi  12 , Raphaël Blanc  12 , Bertrand Lapergue  13 , Arturo Consoli  14 , Sébastien Richard  15   16 , Benjamin Gory  1   2 ; ETIS Registry Investigators
Affiliations

Time from I.V. Thrombolysis to Thrombectomy and Outcome in Acute Ischemic Stroke

François Zhu et al. Ann Neurol. 2021 Mar.

Abstract

Objective: Whether the time from intravenous thrombolysis (IVT) to endovascular treatment (EVT) in patients with acute ischemic stroke has an effect on the functional outcome is unknown.

Methods: The Endovascular Treatment in Ischemic Stroke (ETIS) registry is an ongoing, prospective, multicenter, observational study that perform EVT in France. Data were analyzed from patients treated by IVT and EVT between October 2013 and December 2018 in 6 comprehensive stroke centers. In the primary analysis, we assessed the association of time from IVT administration to start of EVT with functional outcome (measured with the modified Rankin Scale [mRS]), by means of ordinal logistic regression. Secondary end points included angiographic and safety outcomes.

Results: We analyzed 1,986 patients with acute ischemic stroke due to anterior circulation large vessel occlusion who underwent IVT and EVT. An increased IVT to start of EVT time was associated with a worse functional outcome at 90 days (mRS = 0-2, adjusted odds ratio [OR] per 30 minutes increase in time = 0.91, 95% confidence interval [CI] = 0.86-0.96; mRS = 0-1, adjusted OR per 30 minutes increase in time = 0.89, 95% CI = 0.84-0.94), a lower chance of modified Thrombolysis in Cerebral Infarction (mTICI) grade 2b to 3 reperfusion (adjusted OR per 30 minutes increase in time = 0.93, 95% CI = 0.87-0.98), and an increased probability of symptomatic intracerebral hemorrhage (adjusted OR per 30 minutes increase in time = 1.09, 95% CI = 0.99-1.18).

Interpretation: These findings provide a basis for further studies to determine if the functional outcome of patients with stroke can be greatly improved by optimizing IVT to EVT times. ANN NEUROL 2021;89:511-519.

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References

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