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Case Reports
. 2021 Mar;9(3):315-318.
doi: 10.1016/S2213-2600(20)30524-5. Epub 2020 Dec 1.

Successful double-lung transplantation from a donor previously infected with SARS-CoV-2

Laurens J Ceulemans  1 , Jan Van Slambrouck  2 , Paul De Leyn  2 , Herbert Decaluwé  2 , Hans Van Veer  2 , Lieven Depypere  2 , Vincent Ceuterick  3 , Stijn E Verleden  4 , Arno Vanstapel  5 , Stefanie Desmet  6 , Piet Maes  7 , Marc Van Ranst  7 , Piet Lormans  8 , Geert Meyfroidt  9 , Arne P Neyrinck  10 , Bart M Vanaudenaerde  4 , Eric Van Wijngaerden  11 , Saskia Bos  12 , Laurent Godinas  13 , Peter Carmeliet  14 , Geert M Verleden  13 , Dirk E Van Raemdonck  2 , Robin Vos  13
Affiliations
Case Reports

Successful double-lung transplantation from a donor previously infected with SARS-CoV-2

Laurens J Ceulemans et al. Lancet Respir Med. 2021 Mar.
No abstract available

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Figures

Figure 1
Figure 1
Chronological overview of transplant specimen analyses In-house multiplex real-time PCR was used for detection of respiratory bacteria, viruses, and fungi. Normal on chest CT is defined as normal postoperative changes, excluding any signs of fibrosis or infection. FVC=forced vital capacity. HCO3–=bicarbonate. PaCO2=partial pressure of arterial carbon dioxide. PaO2/FiO2=ratio of partial pressure of arterial oxygen to fractional concentration of oxygen in inspired air. PEEP=positive end-expiratory pressure. SARS-CoV-2=severe acute respiratory syndrome coronavirus 2.
Figure 2
Figure 2
Imaging of the donor lungs (A) Chest CT scan of lung allografts before donation excluding inflammation or lung fibrosis (coronal plane). (B) Histology of the peripheral lung biopsy sample revealing normally preserved lung parenchyma without inflammation or fibrotic changes. Arteries are normal, without vasculopathy or thrombi (haematoxylin and eosin). (C) Macroscopic picture of the right donor lung after implantation. (D) Chest CT at 3-month follow-up excluding ground glass opacities, reticular changes, inflammation, or lung fibrosis (coronal plane).
See this image and copyright information in PMC

References

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